Insulin derivatives, process for their preparation, their use an

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 4, 530303, A61K 3726, A61K 3702

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active

051497166

ABSTRACT:
The invention relates to insulin derivatives of the formula III ##STR1## in which R.sup.30 and R.sup.31 together are OH, or R.sup.30 is a radical of a neutral, genetically encodable L-amino acid and R.sup.31 is OH or a physiologically acceptable organic group of basic character having up to 50 carbon atoms, whose synthesis involves 0 to 3 .alpha.-amino acids and whose optional terminal carboxyl function can be present free, as an ester function, as an amide function, as a lactone or reduced to CH.sub.2 OH, and R.sup.A-1 is a radical of a genetically encodable L-amino acid, and physiologically acceptable salts of said insulin derivative of the formula III.

REFERENCES:
patent: 4608364 (1986-08-01), Grau
patent: 4701440 (1987-10-01), Grau
CA 93: 198218P (1980) Roesen et al.
Rosen et al. Biochem J vol. 186 (1980) 945-952.
Rose et al., Advances In Protein Chemistry vol. 37 25-31 (1985).
Advances in Protein Chemistry, Anfinsen et al., Academic Press, pp. 340-347 (1972).
Biochemistry, Lehninger, Worth Publishers Inc., pp. 71-76 (1977).

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