Insulin derivatives, a process for the preparation thereof, the

Details Insulin derivatives, a process for the preparation thereof, the Insulin derivatives, a process for the preparation thereof, the

1995-05-16

1996-04-09

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530303, A61K 3828, C07K 1462

Patent

active

055062024

ABSTRACT:
New insulin derivatives, a process for their preparation and use, and a pharmaceutical formulation containing them are disclosed. The derivatives contain the basic amino acid arginine at the amino-terminal position of the insulin A-chain, and various amino acid substitutions at the carboxyl terminus of the insulin B-chain. The compounds are suitable for the treatment of diabetes mellitus, have a delayed profile of action and are very well tolerated.

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