Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-06-03
2010-10-05
Kolker, Daniel E (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07807396
ABSTRACT:
Estrogen has been shown to increase the expression and activity of amyloid peptide inactivating enzymes in the brain. Peptides have been shown to increase the activity of an amyloid peptide inactivating enzyme. Methods of identifying compounds for, and methods of treating patients with, Alzheimer's Disease is disclosed.
REFERENCES:
patent: 4897389 (1990-01-01), Aroonsakul
patent: 5554601 (1996-09-01), Simpkins et al.
patent: 5624894 (1997-04-01), Bodor
patent: 5952346 (1999-09-01), Heitsch et al.
patent: 6333317 (2001-12-01), Lee et al.
patent: 2002/0091072 (2002-07-01), Eckman et al.
patent: 2004/0038302 (2004-02-01), Nitsch et al.
patent: WO 02/25279 (2001-09-01), None
patent: WO 02/22794 (2002-03-01), None
patent: WO 02/087552 (2002-11-01), None
Blaustein. Minireview: Neuronal steroid hormone receptors: they're not just for hormones anymore. Endocrinology. Mar. 2004;145(3):1075-81. Epub Dec. 11, 2003.
Carson JA, Turner AJ. J Neurochem. Apr. 2002;81(1):1-8.Beta-amyloid catabolism: roles for neprilysin(NEP)and other metallopeptidases?
Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ. Biochem J. Oct. 15, 2000;351 Pt 2:509-16.Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
Eckman EA, Watson M, Marlow L, Sambamurti K, Eckman CB. J Biol Chem. Jan. 24, 2003;278(4):2081-4. Epub Dec. 2, 2002.Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC. J Biochem (Tokyo). Dec. 2001;130(6):721-6.Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.
Haouas H, Morello D, Lavenu A, Billard M, Jasmin C, Boucheix C. Biochem Biophys Res Commun. Feb. 27, 1995;207(3):933-42.Characterization of the 5′ region of the CD10
eutral endopeptidase 24.11 gene.
Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, McCleary CA, Klein RA, Hake AM, Farlow MR. Neurology. Jan. 25, 2000;54(2):295-301.Estrogen for Alzheimer's disease in women: randomized, double-blind, placebo-controlled trial.
Howell S, Nalbantoglu J, Crine P. Peptides. 1995;16(4):647-52.Neutral endopeptidase can hydrolyze beta-amyloid(1-40)but shows no effect on beta-amyloid precursor protein metabolism.
Ishimaru F, Mari B, Shipp MA. Blood. Jun. 1, 1997;89(11):4136-45.The type 2 CD10
eutral endopeptidase 24.11 promoter: functional characterization and tissue-specific regulation by CBF/NF-Y isoforms.
Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Nat Med. Feb. 2000;6(2):143-50.Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.
Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Science. May 25, 2001;292(5521):1550-2.Metabolic regulation of brain Abeta by neprilysin.
Kurochkin IV, Goto S. FEBS Lett. May 23, 1994;345(1):33-7.Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme.
Kurochkin IV. Trends Biochem Sci. Jul. 2001;26(7):421-5.Insulin-degrading enzyme: embarking on amyloid destruction.
Li C, Hersh LB. Arch Biochem Biophys. Oct. 1, 1998;358(1):189-95.Characterization of the promoter region of the rat neprilysin gene.
Li C, Booze RM, Hersh LB. J Biol Chem. Mar. 17, 1995;270(11):5723-8.Tissue-specific expression of rat neutral endopeptidase(neprilysin)mRNAs.
Li C, Guojin Chen, Norma P. Gerard, Craig Gerard, Carmen R Bozic, Louis B. Hersh “Comparison of the structure and expression of the human rat neprilysin (endopeptidase 24.11)- encoding genes.” Gene. 164 (1995) pp. 363-366.
Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. J Neurosci. Mar. 15, 2003;23(6):1992-6.Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.
McDermott JR, Gibson AM. Neurochem Res. Jan. 1997;22(1):49-56.Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.
Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL. Proc Natl Acad Sci U S A. May 13, 2003;100(10):6221-6. Epub May 5, 2003.Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levelsin vivo.
Mohajeri MH, Wollmer MA, Nitsch RM. J Biol Chem. Sep. 20, 2002;277(38):35460-5. Epub Jul. 8, 2002.Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formationin vivo.
Perez A, Morelli L, Cresto JC, Castano EM. Neurochem Res. Feb. 2000;25(2):247-55.Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.
Petanceska SS, Nagy V, Frail D, Gandy S. Exp Gerontol. Dec. 2000;35(9-10):1317-25.Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain.
Pinto FM, Armesto CP, Magraner J, Trujillo M, Martin JD, Candenas ML. Endocrinology. Jun. 1999;140(6):2526-32.Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment.
Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. J Biol Chem. Dec. 4, 1998;273(49):32730-8.Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
Shen R, Sumitomo M, Dai J, Hardy DO, Navarro D, Usmani B, Papandreou CN, Hersh LB, Shipp MA, Freedman LP, Nanus DM. Mol Cell Endocrinol. Dec. 22, 2000;170(1-2):131-42. Identification and characterization of two androgen response regions in the human neutral endopeptidase gene.
Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. J Biol Chem. Jun. 15, 2001;276(24):21895-901. Epub Mar. 6, 2001. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
Song ES, Mukherjee A, Juliano MA, Pyrek JS, Goodman JP Jr, Juliano L, Hersh LB. J Biol Chem. Jan. 12, 2001;276(2):1152-5. Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates.
Tharaux PL, Stefanski A, Ledoux S, Soleilhac JM, Ardaillou R, Dussaule JC.Am J Physiol. Jun. 1997;272(6 Pt 1):C1836-43.EGF and TGF-beta regulate neutral endopeptidase expression in renal vascular smooth muscle cells.
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. J Neurosci. Mar. 1, 2000;20(5):1657-65. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
Abraham R, Myers A, Wavrant-Devrieze F, Hamshere ML, Thomas HV, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ, Jones L. “Substantial Linkage Disequilibrium Across the Insulin-Degrading Enzyme Locus But No Association With Late-Onset Alzheimer's Disease” Hum Genet. Dec. 2001; 109(6):646-52.
Selkoe DJ “Clearing the Brain's Amyloid Cobwebs” Neuron. Oct. 25, 2001;32(2):177-80.
Fricke B, Betz R, Friebe S, “A Periplasmic Insulin-Cleaving Proteinase (ICP) From Acinetobacter Calcoaceticus Sharing Properties With Protease II FromEscherichia coliand IDE From Eukaryotes” Chemical Abstracts, 1995;123:77933X.
Espinosa R III, Lemons RS, Perlman RK, Kuo WL, Rosner MR, Lebeau MM “Localization of the Gene Encoding Insulin-Degrading Enzyme to Human Chromosome 10, Bands Q23-Q25” J-Biochem Genetics, 1992; 116:77617C.
Sakamoto T, “Establishment of Radioimmunoassay for Human Crythrocyte Insulin-Degrading Enzyme (IDE) and Its Clinical Application” 7-Enzymes, 1989; 111:92605N.
Sodeyama N, Mizusawa H, Yamada M,
Emch Gregory S
Kolker Daniel E
McDermott Will & Emery LLP
University of Kentucky Research Foundation
LandOfFree
Insulin degrading enzyme assays for treatment of alzheimer's... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Insulin degrading enzyme assays for treatment of alzheimer's..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulin degrading enzyme assays for treatment of alzheimer's... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4242017