Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-03-19
1995-07-04
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 3, 530303, 530305, 930 10, A61K 3726, C07K 740
Patent
active
054300169
ABSTRACT:
Novel insulin compounds having a desirably protracted insulin action and/or antigenicity are provided.
The novel insulin compounds are represented by the formula II: ##STR1## wherein E individually represents Glu or a neutral amino acid residue which can be coded for by nucleotide sequences, N represents an amino acid residue which can be coded for by nucleotide sequences,
T represents Thr or Arg,
X represents Thr, Ser, Ala or OH, and
Y represents OR or NR.sup.1 R.sup.2, where R, R.sup.1 and R.sup.2 individually represents hydrogen or lower alkyl, but is not present when X represents OH.
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Balschmidt Per
Hansen Finn B.
Lambiris Elias J.
Moezie F. T.
Novo Nordisk A S
Zelson Steve T.
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