Insulin analogs modified at position 29 of the B chain

Details Insulin analogs modified at position 29 of the B chain Insulin analogs modified at position 29 of the B chain

1993-05-05

1996-05-07

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 681, 435 694, 530303, 514 4, C07K 740, D61K 3726

Patent

active

055146465

ABSTRACT:
Analogs of human insulin modified at position 29 of the B chain thereof and, optionally, at other positions, have modified physico-chemical and pharmacokinetic properties and are useful in the treatment of hyperglycemia.

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Bruce H. Frank, Text and Slide Copies of Lecture given at the Conference on Insulin, Self Association and Conformational Studies on Human Proinsulin and Insulin Analogs, University of York, Aug. 29-Sep. 1, 1989.
J. Brange, et al., Monomeric Insulins Obtained by Protein Engineering and their Medical Implications, Nature, 333:679 (1988).
J. Brange, et al., 65. Insulin Analogues with Reduced Association Tendency: Biological Acitvity and Absorption Rate After Subcutaneous Administration, Abstracts, 503A.
Rinderknecht E. et al., The Amino Acid Sequence of Human Insulin-like Growth Factor I and Its Structural Homology with Proinsulin, 253:8, 2769-2776 (1978).
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