Insulin analogs having a modified B-chain

Details Insulin analogs having a modified B-chain Insulin analogs having a modified B-chain

1995-09-21

1998-02-10

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530303, C07K 1462, A61K 3828

Patent

active

057169276

ABSTRACT:
Human insulin analogues having a positively charged amino acid residue, i.e. Lys or Arg, in position B28, further being modified in the C-terminal end of the B-chain from Phe.sup.B24 to the C-terminal amino acid residue and wherein A18, A21 and/or B3 is different from Asn as well as insulin preparations containing the human insulin analogues are provided.

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patent: 4992417 (1991-02-01), Katsoyannis
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Morihara, "Nature", vol. 280, pp. 412-413 (1979).
Brange et al., "Protein Engineering", vol. 3, p. 238 (1987).

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