Insulin activity messengers, their antibodies, and thereof

Details Insulin activity messengers, their antibodies, and thereof Insulin activity messengers, their antibodies, and thereof

1986-04-11

1990-03-06

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 3, 514 8, 514 7, 514 23, 536 187, A61K 3900

Patent

active

049064681

ABSTRACT:
An insulin activity messenger material and its precursor material are disclosed which have been isolated from hapatic plasma membranes that have been incubated with an enzyme known as a phosphtidylinositol-specific phospholipase C. The messenger material comprises a carbohydrate-based compound that exhibits the ability to modulate the activity of the insulin-sensitive enzymes pyruvate dehydrogenase, adenylate cyclase, acetyl CoA carboxyase, and low Km cAMP phosphodiesterase, and thereby effectuate the activity of insulin on the cellular level. The precursor material comprises an inositol containing glycolipid capable of phosphodiesteratic cleavage by a phosphatidylinositol-specific phospholipase C. Numerous diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form, antibodies, and pharmaceutical compositions are likewise set forth.

REFERENCES:
Jarett et al-Chem. Abst., vol. 97 (1982) p. 85761z.

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