Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2006-05-23
2010-10-12
Vanore, David A. (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
C250S281000, C250S282000, C073S028010
Reexamination Certificate
active
07812306
ABSTRACT:
An instrument for non-invasively measuring nanoparticle exposure includes a corona discharge element generating ions to effect unipolar diffusion charging of an aerosol, followed by an ion trap for removing excess ions and a portion of the charged particles with electrical mobilities above a threshold. Downstream, an electrically conductive HEPA filter or other collecting element accumulates the charged particles and provides the resultant current to an electrometer amplifier. The instrument is tunable to alter the electrometer amplifier output toward closer correspondence with a selected function describing particle behavior, e.g. nanoparticle deposition in a selected region of the respiratory system. Tuning entails adjusting voltages applied to one or more of the ion trap, the corona discharge element and the collecting element. Alternatively, tuning involves adjusting the aerosol flow rate, either directly or in comparison to the flow rate of a gas conducting the ions toward merger with the aerosol.
REFERENCES:
patent: 3114877 (1963-12-01), Dunham
patent: 3413545 (1968-11-01), Whitby
patent: 4312180 (1982-01-01), Reif et al.
patent: 4724394 (1988-02-01), Langer et al.
patent: 5026994 (1991-06-01), Westcott et al.
patent: 5352892 (1994-10-01), Mordehai et al.
patent: 5932795 (1999-08-01), Koutrakis et al.
patent: 5973904 (1999-10-01), Pui et al.
patent: 6003389 (1999-12-01), Flagan et al.
patent: 6544484 (2003-04-01), Kaufman et al.
patent: 6568245 (2003-05-01), Kaufman
patent: 6905029 (2005-06-01), Flagan
A. Reinert and H. Tammet, Electrical Simulation Of Aerosol Deposition In Lungs, 1995, J. Aerosol Sci., vol. 26, pp. 5613-5614.
A. Reinert and H. Tammet, Electrical Simulation of Aerosol Deposition in Lungs, 1995, J. Aerosol Sci., vol. 26, pp. 5613-5614.
Fissan et al., “Rationale and principle of an instrument measuring lung deposited nanoparticle surface area,” Journal of nanoparticle Research (2006) (7 pages).
Search Report dated, Oct. 13, 2009.
Asbach et al., “Conceptual limitations and extensions of lung-deposited Nanoparticle Surface Area Monitor (NSAM),” Nanoparticles and Occupational Health2008, pp. 101-109.
Brock, “An Instrument for Fast-Response Measurement of Particle Size Distributions in the 4-60 nm Diameter Size Range,” Second Joint NSF-ESF Symposium on “Nanoparticles: Technologies and Application” 1999, pp. P15-1-P15-4, Tacoma, Washington, USA.
Chen, “A Nanometer Aerosol Size Analyzer for Rapid Size Distribution Measurements,” Second Joint NSF-ESF Symposium on “Nanoparticles: Technologies and Application” 1999, pp. P17-1-P17-2, Tacoma, Washington, USA.
Fissan et al., “Particle Surface Area Concentration Measurement for Smoke Characterization,” Institute of Energy and Environmental Technology, 14thInt'l Converence on Automatic Fire Detection AUBE, 2009, Sep. 8-10, 2009, Duisburg Germany.
Fissan et al., “Rationale and principle of an instrument measuring lung deposited nanoparticle surface area,” Journal of Nanoparticle Research, 2007, pp. 53-59.
Friedlander et al., “Emerging Issues in Nanoparticle Aerosol Science and Technology,” Journal of Nanoparticle Research, 2004, pp. 313-320.
Jung et al., “Response of DC and PAS to size fractionated particles,” Dept. of Mechanical Engineering, University of Minnesota, 5thETH Conference on Nanoparticle Measurement, 2001.
Ku et al., “Comparing Aerosol Surface-area measurements of monodisperse ultrafine silver agglomerates by mobility analysis, transmission electron microscopy and diffusion charging,” Journal of Aerosol Science, 2005, pp. 1108-1124, Cincinnati, Ohio, USA.
Li et al., “Evaluation of an electrical aerosol detector (EAD) for the aerosol integral parameter measurement,” Journal of Electrostatics, 2009, pp. 1-9.
Medved et al., “A new Corona-Based Charger for Aerosol Particles,” Journal of Aerosol Science, 2000, pp. S616-S617.
Qi et al., “The Effect of Particle Pre-Existing Charge on Unipolar Charging and Its Implication on Electrical Aerosol Measurements,” Aerosol Science and Technology, 2009, pp. 232-240.
Qi et al., “Experimental study of a new corona-based unipolar aerosol charger,” Journal of Aerosol Science, 2007, pp. 775-792.
Reinhart et al., “Electrical Simulation of Aerosol Deposition in Lungs,” 1995, pp. S613-S614.
Shin et al., “The effect of dielectric constant of materials on unipolar diffusion charging of nanoparticles,” 2009, p. 463-468.
Tsi, “Measuring Nanoparticle Exposure,” Application Note NSAM-001, 2008, pp. 1-7.
Tsi, “The Nanoparticle Surface Area Monitor reports the surface area of inhaled particles deposited in the lung” Application Note NSAM-001, 2008.
Tsi, “Model 3070A Electrical Aerosol Detector, a fast aerosol concentration detector for wide dynamic range” 2004.
Tsi, “Model 3550, Nanoparticle Surface Area Monitor, Measures lung-deposited surface area of inhaled particles,” 2006.
Tsi, “AeroTrak 9000 Nanoparticle Aerosol Monitor, The AeroTrak 9000 Nanoparticle Aerosol Monitor indicates the surface area of particles deposited in the lung,” 2006.
Tsi, “AeroTrak 9000 Nanoparticle Aerosol Monitor Theory of Operation” 2009.
Wilson et al., “Use of Electrical Aerosol Detector as an Indicator for the Total Particle Surface Area Deposited in the Lung,” Proceedings of 2004 A&WMA, paper #37, 2004, pp. 1-16.
Wilson et al., “Use of the electrical aerosol detector as an indicator of the surface area of fine particles deposited in the lung,” J. Air Waste Manag Assoc., 2007.
Woo et al., “Use of Continuous Measurements of Integral Aerosol Parameters to Estimate Particle Surface Area,” Aerosol Science and Technology, 2001, pp. 57-65.
Fissan et al.,Personal Sampler for Measuring the Surface Area of Particles Deposited in the Lung, Abstracts AAAR, 2003, pp. 280.
Esa,Corona Charged Aerosol Detection Technology, www.coronacad.com/CAD—Overview.htm, Nov. 2004, 4 pages.
Fissan et al.,Ecologically Sustainable Nanoparticle Technology, International Symposium on Environmental Nanotechnology, Dec. 2003, pp. 1-13.
British Associate's response to UK Intellectual Property Office (UKIPO) correspondence, dated Apr. 14, 2010.
British Search Report dated May 26, 2010.
Fissan Heinz
Kaufman Stanley L.
Pui David Y. H.
Trampe Andreas
Johnston Phillip A.
Patterson Thuente Christensen Pedersen , P.A.
TSI Incorporated
Vanore David A.
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