Instrument for separating ions in time as functions of...

Electrolysis: processes – compositions used therein – and methods – Electrolytic coating – Depositing predominantly single metal coating

Reexamination Certificate

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C205S282000

Reexamination Certificate

active

07077944

ABSTRACT:
An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.

REFERENCES:
patent: 3621240 (1971-11-01), Cohen et al.
patent: 3812355 (1974-05-01), Wernlund et al.
patent: 3845301 (1974-10-01), Wernlund et al.
patent: 3902064 (1975-08-01), Young
patent: 4261698 (1981-04-01), Carr et al.
patent: 5070240 (1991-12-01), Lee et al.
patent: 5117107 (1992-05-01), Guilhaus et al.
patent: 5210412 (1993-05-01), Levis et al.
patent: 5504326 (1996-04-01), Reilly et al.
patent: 5510613 (1996-04-01), Reilly et al.
patent: 5622824 (1997-04-01), Koster
patent: 5640011 (1997-06-01), Wells
patent: 5763878 (1998-06-01), Franzen
patent: 5905258 (1999-05-01), Clemmer et al.
patent: 6498342 (2002-12-01), Clemmer
patent: 6744043 (2004-06-01), Loboda
patent: WO 98/40520 (1998-09-01), None
patent: WO 98/56029 (1998-12-01), None
patent: WO 00/17908 (2000-03-01), None
“Ion Mobility Spectrometry”, Analytical Chemistry, vol. 62, No. 23, Dec. 1, 1990, pp. 1201A-1209A.
Abstract “Proceedings of the 44thASMS Conference”, (1996), R. Guevremont, K.W.M. Siu, and L. Ding, p. 1090.
PCT International Application No. PCT/US98/11129, International Publication No. WO 98/56029, published Dec. 10, 1998.
PCT International Application No. PCT/US97/14001 International Publication No. WO 98/07177, published Feb. 19, 1998.
Shella C. Henderson et al., “ESI/Ion Trap/Ion Mobility/Time-of-Flight Mass Spectrometry for Rapid and Sensitive Analysis of Biomolecular Mixtures,” Anal. Chem. 1999, 71, pp. 291-301.
Cherokee S. Hoaglud et al., “Three-Dimensional Ion Mobility/TOFMS Analysis of Electrosprayed Biomolecules,” Anal. Chem. 1998, 70, pp. 2236-2242.
Roger Guevremont et al., “Combined Ion Mobility/Time-of-Flight Mass Spectrometry Study of Electrospray-Generated Ions,” Anal. Chem. 1997, 69, pp. 3959-3965.
PCT International Application No. PCT/US99/01292, International Publication No. WO 99/38194, published Jul. 29, 1999.
European Patent Publication No. EP 0898 297 A2, Bulletin Aug. 1999, published Feb. 24, 1999.
R. Graham Cooks et al., “Spectrometers, Mass,” XP-002155452, Encyclopedia of Applied Physics, vol. 19, 1997 VCR Publishers, Inc. pp. 289-330.
Charles S. Harden et al. “Detection of Methyl Isocyanate in Air with the Use of Hand-Held Ion Mobility Spectrometers,” Field Analytical Chemistry and Technology 1997 John Wiley & Sons, Inc. pp. 285-294.
Anne E. Counterman et al., “High-Order Structure and Dissociation of Gaseous Peptide Aggregates that are Hidden in Mass Spectra,” Am. Soc. for Mass Spec. 1998 Elsevier Science Inc. pp. 743-759.
Roger Guevremont et al., “High Field Asymmetric Waveform Ion Mobility Spectrometry—Mass Spectrometry: An Investigation of Leucine Enkephalin Ions Produced by Electrospray Ionization,” Am. Soc. for Mass Spec., 1999 Elsevier Science Inc. pp 492-501.
Barnett, David A., Purves, Randy W. and Guevremont, Roger, “Isotope separation using high=field asymmetric waveform ion mobility spectrometry,” Nuclear Instruments & Methods in Physics Research, Section A, pp. 179-185, 2000.

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