Optics: measuring and testing – By shade or color – Fluid color transmission examination
Patent
1987-08-11
1990-06-26
McGraw, Vincent P.
Optics: measuring and testing
By shade or color
Fluid color transmission examination
250576, 356440, 356 39, G01N 2127, G01N 2131
Patent
active
049366823
ABSTRACT:
An analytic instrument for kinetically measuring light absorption characteristics of a plurality of independent samples contained in disposable test tubes arranged in a circular pattern about a single light source. The instrument is designed to be used with a host personal computer and is not specific to any particular type of assay. The instrument obtains and temporarily stores raw data in the form of digitized output signals from the plurality of photodetectors and periodically passes them to the host computer. An incubator has test tube wells arranged in a circular array equidistant from a single incandescent light source. The circular symmetry controls the thermal gradients in the incubator such that all of the samples are disposed on the same isotherm and all of the photodetectors are disposed on the same isotherm. The instrument is designed for use with disposable test tubes, and sources of error arising from optical variation in such test tubes are minimized by providing a separate detector for each tube and by holding the tube fixed with respect to the detector. The light output from the single light source is continuously monitored and is kept constant.
REFERENCES:
patent: Re31108 (1982-12-01), Ginsberg et al.
patent: 3041146 (1962-06-01), Kuzell
patent: 3141948 (1964-07-01), Young
patent: 3267364 (1966-08-01), Page et al.
patent: 3522436 (1970-08-01), Posgate
patent: 3746864 (1973-07-01), Tick et al.
patent: 3811780 (1974-05-01), Liston
patent: 3873273 (1975-03-01), Moran et al.
patent: 3877817 (1975-04-01), Ralston
patent: 3890510 (1975-06-01), Sturm
patent: 3905482 (1975-09-01), Knulst
patent: 3918817 (1975-11-01), Posgate
patent: 3964867 (1976-06-01), Berry
patent: 3977794 (1976-08-01), Liedholz
patent: 4038555 (1977-07-01), Freeman
patent: 4055395 (1977-10-01), Honkawa et al.
patent: 4061469 (1977-12-01), DuBose
patent: 4213764 (1980-07-01), O'Connor
patent: 4257708 (1981-03-01), Fukuda
patent: 4276383 (1981-06-01), Leighton et al.
patent: 4285906 (1981-08-01), Meltzer et al.
patent: 4448534 (1984-05-01), Wertz et al.
"Toxinometer ET-201", Wako Pure Chemical Industries, Ltd., Osaka, Japan.
"The Lal Update", Associates of Cape Cod, Inc., Woods Hole, MA, vol. 4, No. 2, Jun. 1986.
"The LAL-4000 Automatic Endotoxin Detection System", Associates of Cape Cod, Inc., Woods Hole, MA.
"MS-2 Microbiology System and Research System", cover letter, Abbott Laboratories, Irving, TX.
"The LAL-4000 Automatic Endotoxim Detection System", Pyrotell Benthos Clinical Systems, North Falmouth, MA.
"MS-2 A Rapid Automated Microbiology System for Urine Testing", Abbott Laboratories, Irving, TX.
"MS-2 Microbiology System, Now You Get Answers, Not Just Clues", Abbott Laboratories, Irving, TX.
Levin, J. et al., "Clottable Protein in Limulus: Its Localization and Kinetics of Its Coagulation by Endotoxin", Throb. Diath. Haemorrh., 19:186-197 (1968).
Jorgensen, J. H., et al., "Automation of the Limulus Amoebocyte Lysate Test by Using the Abbott MS-2 Microbiology System", Appl. Environ. Microbiol. 41:1316-1320.
Oishi, H., et al., "Automated Limulus Amoebocyte Lysate (LAL) Test for Endotoxin Analysis Using a New Toxinometer ET-201", J. Parenter, Sci. Technol., 39:194-199.
Novitsky, T. J., et al., "Automated LAL Testing of Parenteral drugs in the Abbott MS-2", J. Parenter. Sci. Technol., 36:11-16 (1982).
Novitsky, T. J., et al., "Design Criteria and Evaluation of the LAL-4000 for Kinetic Turbidimetric LAL Assay", Detection of Bacterial Endotoxins With The Limulus Amebocyte Lysate Test, Proceeding Woods Hole Conf. On Endotoxin (1985).
Associates of Cape Cod, Inc.
McGraw Vincent P.
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