Instrument for constructing tissue arrays

Chemistry: molecular biology and microbiology – Apparatus – Including condition or time responsive control means

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4352841, 4352862, 4353071, 4353079, 422 63, C12M 136

Patent

active

061035181

ABSTRACT:
A simple, robust and precise instrument for constructing tissue arrays. The instrument includes multiple punches mounted on a punch platform, the punch platform displaceable between precisely defined positions. Mechanical detentes or stops are provided which mechanically arrest the movement of the punch platform in the precisely defined positions. This arrangement greatly saves time and improves accuracy over use of conventional precision linear positioning means. By the simple step of moving the punch platform from a first position to a second position, either punch can be quickly brought into operating position (and the other moved into a non-interfering position) by either manually or by automatic means, making it possible to quickly alternate from one punch to the other.

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Juha Kononen, et al.; Tissue microarrays for high-throughput molecular profiling of tumor specimens; Nature Medicine; vol. 4; No. 7; Jul. 1998.

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