Instant oral-release capsule containing nifedipine

Details Instant oral-release capsule containing nifedipine Instant oral-release capsule containing nifedipine

1988-11-14

1993-04-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424456, 424452, A61K 965

Patent

active

052001920

ABSTRACT:
The invention concerns an instant oral-release capsule containing an aqueous or aqueous alcoholic solution of nifedipine, containing a polyalkylene glycol and a polyoxyethylene ester component, the amount of the ester component in the solution being sufficient to prevent precipitation of nifedipine in the mouth of a patient after release of the solution from the capsule. Preferably, the ester component is an ethoxylated hydrogenated castor oil Cremophor RH40. The solution may further contain a second glycol component, especially glycerol.

REFERENCES:
patent: 3784684 (1974-01-01), Bossert et al.
patent: 4689233 (1987-08-01), Dvorsky et al.
patent: 4690823 (1987-09-01), Lohner et al.
patent: 4695450 (1987-09-01), Bauer et al.
patent: 4904699 (1990-02-01), Bauer

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