Insoluble gas-filled microspheres containing a hydrophobic barri

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 4904

Patent

active

06063362&

ABSTRACT:
The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.

REFERENCES:
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4985550 (1991-01-01), Charpoit et al.
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5149543 (1992-09-01), Cohen et al.
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5234680 (1993-08-01), Rogers, Jr. et al.
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5409688 (1995-04-01), Quay
patent: 5413774 (1995-05-01), Schneider et al.
patent: 5446023 (1995-08-01), Pavia et al.
patent: 5508021 (1996-04-01), Grinstaff et al.
patent: 5536490 (1996-07-01), Klaveness
patent: 5540909 (1996-07-01), Schutt
patent: 5585112 (1996-12-01), Unger et al.
patent: 5626833 (1997-05-01), Schutt et al.
Dyatkin et al., "The perfluoro-t-butyl anion in the synthesis of organofluorine compounds" Russian Chem. Rev. (1976) 45(7):607-614, translated from: Uspekhi Khimii (1976) 45:1205-1221.
Knunyants, I.L., et al., Synthesis of Fluoroorganic Compounds, (1985) Springer-Verlag, New York, pp. 1-299.
March, J., ed., Advanced Organic Chemistry, (1992) John Wiley & Sons, Inc., New York, pp. 417-418.
Olah, G.A., et al., Synthetic Fluorine Chemistry, (1992) John Wiley & Sons, Inc., New York, pp. 227-245.
Ophir et al., "Contrast agents in diagnostic ultrasound" Ultrasound in Med.& Biol. (1989) 15(4):319-333.
Schneider et al., "Polymeric microballoons as ultrasound contrast agents. Physical and ultrasonic properties compared with sonicated albumin" Invest. Radiol. (1992) 27(2): 134-139.
Wen et al., "Thermodynamics of some perfluorocarbon gases in water" J. Solution Chem. (1979) 8(3):225-246.
Zeifman et al., "The chemistry of perfluoroisobutene" Russian Chem. Rev. (1984) 53(3):256-273, (translated from: Uspekhi Khimii (1984) 53:431-461.) .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Insoluble gas-filled microspheres containing a hydrophobic barri does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insoluble gas-filled microspheres containing a hydrophobic barri, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insoluble gas-filled microspheres containing a hydrophobic barri will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-256203

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.