Insoluble drug delivery

Details Insoluble drug delivery Insoluble drug delivery

2005-12-13

2005-12-13

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S494000, C424S496000, C424S497000, C424S498000, C424S489000

Reexamination Certificate

active

06974593

ABSTRACT:
Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.

REFERENCES:
patent: 2803582 (1957-08-01), Cherney
patent: 3137631 (1964-06-01), Soloway
patent: 3216897 (1965-11-01), Drantz
patent: 3274063 (1966-09-01), Nieper et al.
patent: 3594476 (1971-07-01), Merrill
patent: 3715432 (1973-02-01), Merrill
patent: 3755557 (1973-08-01), Jacobs
patent: 3794476 (1974-02-01), Michalik et al.
patent: 3937668 (1976-02-01), Zolle
patent: 3960757 (1976-06-01), Morishita et al.
patent: 3965255 (1976-06-01), Bloch et al.
patent: 3998753 (1976-12-01), Antoshkiw et al.
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4053585 (1977-10-01), Allison et al.
patent: 4056635 (1977-11-01), Glen et al.
patent: 4073943 (1978-02-01), Wretlind et al.
patent: 4078052 (1978-03-01), Papahadjopoulos
patent: 4089801 (1978-05-01), Schneider
patent: 4102806 (1978-07-01), Kondo et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4133874 (1979-01-01), Miller et al.
patent: 4145410 (1979-03-01), Sears
patent: 4147767 (1979-04-01), Yapel, Jr.
patent: 4186183 (1980-01-01), Steck et al.
patent: 4219548 (1980-08-01), Reller
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4241046 (1980-12-01), Papahadjopoulos et al.
patent: 4271196 (1981-06-01), Schmidt
patent: 4280996 (1981-07-01), Okamoto et al.
patent: 4298594 (1981-11-01), Sears et al.
patent: 4302459 (1981-11-01), Steck et al.
patent: 4308166 (1981-12-01), Marchetti et al.
patent: 4309421 (1982-01-01), Ghyczy et al.
patent: 4316884 (1982-02-01), Alam et al.
patent: 4320121 (1982-03-01), Sears
patent: 4325871 (1982-04-01), Sasaki et al.
patent: 4328222 (1982-05-01), Schmidt
patent: 4329332 (1982-05-01), Couvreur et al.
patent: 4331654 (1982-05-01), Morris
patent: 4332795 (1982-06-01), Ghyczy et al.
patent: 4332796 (1982-06-01), Los
patent: 4340594 (1982-07-01), Mizushima et al.
patent: 4345588 (1982-08-01), Widder et al.
patent: 4351831 (1982-09-01), Growdon et al.
patent: 4356167 (1982-10-01), Kelly
patent: 4369182 (1983-01-01), Ghyczy et al.
patent: 4378354 (1983-03-01), Ghyczy et al.
patent: 4394372 (1983-07-01), Taylor
patent: 4397846 (1983-08-01), Weiner et al.
patent: 4411894 (1983-10-01), Schrank et al.
patent: 4421747 (1983-12-01), Ghyczy et al.
patent: 4427649 (1984-01-01), Dingle et al.
patent: 4448765 (1984-05-01), Ash et al.
patent: 4483847 (1984-11-01), Augart
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4492720 (1985-01-01), Mosier
patent: 4515736 (1985-05-01), Deamer
patent: 4529561 (1985-07-01), Hunt et al.
patent: 4532089 (1985-07-01), MacDonald
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4613505 (1986-09-01), Mizushima et al.
patent: 4622219 (1986-11-01), Haynes
patent: 4675236 (1987-06-01), Ohkawara et al.
patent: 4687762 (1987-08-01), Fukushima et al.
patent: 4725442 (1988-02-01), Haynes
patent: 4756910 (1988-07-01), Yagi et al.
patent: 4761288 (1988-08-01), Mezei et al.
patent: 4762720 (1988-08-01), Jizomoto
patent: 4766046 (1988-08-01), Abra et al.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4801455 (1989-01-01), List et al.
patent: 4803070 (1989-02-01), Cantrell et al.
patent: 4806350 (1989-02-01), Gerber
patent: 4806352 (1989-02-01), Cantrell
patent: 4826687 (1989-05-01), Nerome et al.
patent: 4839111 (1989-06-01), Huang
patent: 4973465 (1990-11-01), Baurain et al.
patent: 5030453 (1991-07-01), Lenk et al.
patent: 5043280 (1991-08-01), Fischer et al.
patent: 5091187 (1992-02-01), Haynes
patent: 5091188 (1992-02-01), Haynes
patent: 5100591 (1992-03-01), Leclef et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5169433 (1992-12-01), Lindsay et al.
patent: 5246707 (1993-09-01), Haynes
patent: 5272137 (1993-12-01), Blasé
patent: 5302401 (1994-04-01), Liversidge et al.
patent: 5320906 (1994-06-01), Eley et al.
patent: 5340564 (1994-08-01), Illig et al.
patent: 5470583 (1995-11-01), Na et al.
patent: 5510118 (1996-04-01), Bosche et al.
patent: RE35338 (1996-09-01), Haynes
patent: 5637625 (1997-06-01), Haynes
patent: 5776486 (1998-07-01), Castor et al.
patent: 5874029 (1999-02-01), Subramaniam et al.
patent: 6177103 (2001-01-01), Pace et al.
patent: 6576264 (2003-06-01), Henriksen et al.
patent: 2 513 797 (1975-10-01), None
patent: 2 938 807 (1980-11-01), None
patent: 0 052 322 (1982-05-01), None
patent: 0 272 091 (1988-06-01), None
patent: 0 322 687 (1989-05-01), None
patent: 0 322 687 (1989-07-01), None
patent: 0 418 153 (1991-03-01), None
patent: 0 456 670 (1991-11-01), None
patent: 0 456 764 (1991-11-01), None
patent: 0 499 299 (1992-08-01), None
patent: 0 542 314 (1993-05-01), None
patent: 0 542 314 (1993-05-01), None
patent: 0 0601 618 (1994-06-01), None
patent: 0 601 618 (1994-06-01), None
patent: 0 706 821 (1996-04-01), None
patent: 0 744 992 (1996-12-01), None
patent: 2046094 (1980-11-01), None
patent: 56167616 (1980-05-01), None
patent: 63233915 (1980-05-01), None
patent: 55141407 (1980-11-01), None
patent: 60208910 (1985-10-01), None
patent: 63502117 (1988-08-01), None
patent: 1502590 (1989-07-01), None
patent: WO 8500011 (1985-01-01), None
patent: WO 8704592 (1987-08-01), None
patent: WO 8804924 (1988-07-01), None
patent: WO 9104011 (1991-04-01), None
patent: WO 95/21688 (1995-08-01), None
patent: WO 09714407 (1997-04-01), None
patent: WO 9807414 (1998-02-01), None
patent: WO 9952504 (1999-10-01), None
Ross et al., Aqueous Solutions of Surface-Active Solutes:,Collodial Systems and Interfaces, © 1988, pp. 148-151.
Sande et al., “Antimicrobial Agents: Antifungal and Antiviral Agents”, pp. 1219-1222.
Bittman, Robert, “Sterol-Polyene Antibiotic Complexation: Probe of Membrane Structure,”Lipids, vol. 13, No. 10, pp. 686-691 (1978).
Mishra et al., “Scientifically Speaking: Novel Injectable Formulations of Water-Insoluble Drugs”,Controlled Release Newsletter, vol. 17, Issue 2, Jun. 2000, pp. 21-30.
Bangham et al., Diffusion of Univalent Ions Across the Lamellae of Wollen Phospholipids,J. Mol. Biol.(1965) 13, pp. 238-252.
Huang et al., “Interaction of the N-terminus of Sterol Carrier Protein 2 with Membranes: Role of Membrane Curvature”,Biochem. J, 1999, vol. 8, pp. 593-603.
Gregoriadis, Gregory, “The Carrier Potential of Llposomes in Biology and Medicine”,New Engl. J. Med., 1976, vol. 295, No. 13, pp. 704-710.
Cudd et al., “Liposomes Injected Intravenously into Mice Associates with Live Mitochondria, ”Biochem. Biophys Acta, 1984, vol. 394, pp. 323-334.
Benz et al., “Electrical Capacity of Black Lipid Films and of Lipid Bilayers Made from Monolayers”,Biochem. Biophys. Acta, 1975, vol. 394, pp. 323-334.
Goodman and Gillman's, “The Pharmacological Basis of Therapeutics,” 7thEd.,MacMillan Publishing Co., New York (1985), Chap. 15, p. 312.
Cherney, L.S., “Tetracaine Hydroiodide: A Long Lasting Local Anesthetic Agent for the Relief of Postoperative Pain”,Anest. Analg., 1963, vol. 42, No. 4, pp. 477-481.
Haynes et al., “Metal-Ligand Interactions in Organic Chemistry and Biochemistry”, B. Pullman and N. Goldblum (Eds.) part 2, 1977, pp. 189-212.
Haynes et al., Ultra-Long Duration Local Anesthesia Produced by Injection of Lecithin-coated Methxyfluorene Microdroplets,Anesthesiology, 1985 vol. 63, No. 5, pp. 490-499.
Methxyfluorene Microdroplets,Anesthesiology, 1985 vol. 63, No. 5, pp. 490-499.
Haynes et al., “Ultra-Long Duration local Anesthesia Produced by Intra-Dermal Injection of Lecithin-Coated Methoxyfluorence Microdroplets”,Proceed. Intern. Symp. control. Rel. Bioact. Mater., 1987, vol. 14, pp. 293-294.
Kirkpatrick et al., “Local Anesthetic Efficacy of Methozyflurance Microdroplets in Man,”Anesthesiology, 1987, 67(3A), p. A254.
Wu et al., “Pharmacokinetics of Methoxyflurance After Its Intra-Dermal Injection as Lecithin-Coated Microdroplets,&

Affiliated with

Also associated with

Rating

Insoluble drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insoluble drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insoluble drug delivery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3492254