Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1981-04-07
1984-12-04
Rosen, Sam
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435175, A61K 3748
Patent
active
044864086
ABSTRACT:
A therapeutic preparation, and a process of using the preparation, for the control of tumor growth and immune diseases. The preparation is an immobilized cytotoxic enzyme system which is carried by an insoluble substrate that is administered into the mammalian subject by injection or implantation. The preferred embodiment of the preparation uses a polymerized albumin carrier containing immobilized glucose oxidase and peroxidase. The immobilized enzyme system is prepared in the form of small particles that can be administered either by implantation or by injection into tumor-bearing mammals. To date, antibacterial activity has been demonstrated only in vitro. Intraperitoneal injection into rats bearing Novikoff hepatomas or into mice bearing B16-F1 melanomas or L1210 (Lymphoid) tumors has resulted in the selected killing of tumor tissues. Several daily administrations are required to achieve complete destruction of the tumor. Additionally, the preparation is also active as a stimulant of the specific immune response to neoplasia. Its effect on the immune system could be useful in the stimulation of the immune system in diseases where the action of the endogenous immune system is insufficient.
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Okuda et al., "New Type of Antibody-Enzyme Conjugate which Specifically Kills Candida albicans", Feb. 1980, Infection and Immunity, vol. 27, No. 2, pp. 690-692.
Kaetsu et al., "Immobilization of Enzymes for Medical Uses on Plastic Surfaces by Radiation-Induced Polymerization at Low Temperatures", 1980, Journal of Biomedical Materials Research, vol. 14, pp. 199-210.
Schultz et al., "Chemical Nature and Biological Activity of Myeloperoxidase", 1972, Molecular Basis of Electron Transport, Academic Press, N.Y., N.Y., pp. 301-321.
Lamattina Frank J.
Rosen Sam
Singer Donald J.
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