Insolubilized proteins and immunoassays utilizing them

Details Insolubilized proteins and immunoassays utilizing them Insolubilized proteins and immunoassays utilizing them

1979-01-22

1981-03-03

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

252408, 424 12, 435177, 435180, 435181, G01N 3354

Patent

active

042538440

ABSTRACT:
Insolublized antibodies, F(ab').sub.2 fragments thereof and protein antigens are made by coupling to a water-insoluble substrate using a bridging agent which covalently binds to sulphur atoms in antibody, fragment or protein rather than to free amino groups therein. This is preferably effected by using a chloracetyl-terminated bridging agent. Immunoassays utilizing these insolubilized reagents are described. One novel class of bridging agents comprising anhydride and monochloracetyl end groups, which is useful for making the said reagents, is also disclosed.

REFERENCES:
patent: 3639558 (1972-02-01), Csizmas
patent: 4070246 (1978-01-01), Kennedy
patent: 4081244 (1978-03-01), Polito
patent: 4108976 (1978-08-01), Reese
patent: 4140662 (1979-02-01), Reckel
patent: 4175073 (1979-11-01), Carlsson
patent: 4181636 (1980-01-01), Fischer

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