Inside-out crosslinked and commercial-scale hydrogels, and sub-m

Details Inside-out crosslinked and commercial-scale hydrogels, and sub-m Inside-out crosslinked and commercial-scale hydrogels, and sub-m

1998-03-03

1999-11-02

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

2101982, 2105021, 210635, 210656, 96101, 502404, B01D 1508, B01D 3900, C02F 128

Patent

active

059773456

ABSTRACT:
Relating to chromatographic processes and ion-exchange and affinity matrices, a spatial installation method for a bifunctional reagent that crosslinks and/or activates a polymer matrix is disclosed, with inside-outside installation of a bifunctional reagent on and within a polymer matrix. The polymer matrix is cellulose, agarose, or chitosan particles. The installation may be followed by inside-outside ligand attachment, by further reacting the matrix with a ligand or ionic group so that a higher concentration of ligand or ionic moiety occurs on the intra-particle volume than the outer matrix surface.

REFERENCES:
patent: 5328603 (1994-07-01), Velander et al.
"Optimization of Pressure-Flow Limits, Strength, Intraparticle Transport and Dynamic Capacity by Hydrogel Solids Content and Bead Size in Cellulose Immunosorbents", Journal of Chromatograpy, 648 (1993) 79-90, Jeffrey A. Kaster et al.
"A Systematic Approach to Screening Ion-Exchange Chromatography Media for Process Development", Y. Dasarathy et al., BioPharm, Sep. 10, 1996, pp. 42-45.
"Analysis of Nonequilibrium Adsorption/Desorption Kinetics and Implications for Analytical and Preparative Chromatograpy", R. Whitley et al., Ind. Eng. Chem. Res. 1993, 32, 149-159.
"Predictability of Chromatographic Protein Separations, Study of Size-Exclusion Media with Narrow Particle Size Distributions", A. Athalye et al., Journal of Chromatography, 589 (1992) 71-85.

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