Insecticidal toxins from the parastic wasp, bracon hebetor

Details Insecticidal toxins from the parastic wasp, bracon hebetor Insecticidal toxins from the parastic wasp, bracon hebetor

1994-08-10

1996-09-10

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530858, 424538, A61K 3816, C07K 14435, A01N 2700, A01N 6300

Patent

active

055545920

ABSTRACT:
Novel polypeptides are isolated from the venom of the parasitic wasp, Bracon hebetor, and are designated Brh-I to Brh-V. These polypeptides are paralytic and/or toxic to insects. The entire amino acid sequence of Brh-I and the DNA encoding it is also determined. These polypeptides may be cloned into a baculovirus, and used for insect control.

REFERENCES:
Slavnova et al. 1987. "Effect of Toxins from the venom of the Ichneumon Habrobracton hebetor (SAY) . . . " Doklady Akademii Nauk SSR 297(2):492-494.
Visser et al. 1983. "Characterization of Two Paralysing Protein Toxins (A-MTX and B-MTS) . . . " Comp. Biochem. Physiol. 75B(3):523-530.
Piek et al. 1982. "The Pharmacology of Microbracon Venom" Comp. Biochem. Physiol. 72C:303-309.
Spanjer et al. 1977. "Two Different Paralysing Preparations Obtained from a Homogenate of the Wasp Microbracon hebetor"Toxicon 15:413-421.
Visser et al. 1976. "Isolation and Some Biochemical Properties of a Paralysing Toxin from the Venom . . . " Toxicon 14:357-370.
Walther et al. 1983. "Block of Synaptic Vesicle Exocytosisi Without Block of Ca.sup.2+-Influx . . . " Neuroscience 9(1):213-224.
Drenth 1974. "Susceptibility of Different Species of Insects to an Extract of the Venom Gland of the Wasp Microbracon hebetor" (SAY) Toxicon 12:189-192.
Beard 1971. "Production and Use of Venom by Bracon brevicornis (WESM)" in Toxins of Animal and Plant Origin vol. 1 deVries et al., Eds. Gordon and Breach Science Publishers, New York, pp. 181-190.
Piet 1966 "Site of Action of Venom of Microbracon hebetor SAY (Braconidae, Hymenoptera)" J. Insect Physiol. 12:561-568.

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