Insecticidal plectoxins from Plectreurys tristis

Details Insecticidal plectoxins from Plectreurys tristis Insecticidal plectoxins from Plectreurys tristis

1994-03-30

1995-11-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 424936, 536 235, 935 57, C12N 701, C12N 1563, C12N 1512, A61K 4500

Patent

active

054707358

ABSTRACT:
Novel plectoxins isolated from the Primitive Hunting Spider, Plectreurys tristis are described, and their amino acid sequences are presented. These are toxic to various groups of insects, including Lepidopterans. A particularly potent plectoxin is Plt-VI. The plectoxins may be cloned into a baculovirus vector and hasten its speed of kill.

REFERENCES:
patent: 4745051 (1988-05-01), Smith et al.
patent: 5041379 (1991-08-01), Fraser et al.
Branton et al. 1987. "Neurotoxins from Plectreurys Spider Venom are Potent Presynaptic Blockers in Drosophila" J. Neurosci. 7(12) 4195-4200.
Jackson et al. 1986. "Effects of Spider Venoms on Transmission Mediated by Non-N-Methyl-D-Aspartate Receptors" Excitatory Amino Acid Transmission Hicks et al. Eds. Alan R. Liss, Inc., NY 51-54.
Branton et al. (1993) Nature 365: 498-499.

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