Insect-specific paralytic neurotoxin genes for use in biological

Details Insect-specific paralytic neurotoxin genes for use in biological Insect-specific paralytic neurotoxin genes for use in biological

1990-10-04

1993-11-30

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

536 235, 4352351, 435 691, 4351723, 4353201, C12N 701, C12N 1512

Patent

active

052663175

ABSTRACT:
Genes encoding insect-specific paralytic neurotoxins, particularly those of insect-parasitic mites, including Pyemotes, are described. Recombinant DNA molecules in which the neurotoxin coding sequences are placed under the control of heterologous promoters are also described. Such molecules are useful for the development of biological insect control agents which produce insect-toxic levels of the neurotoxin. Specifically described are genetically altered baculoviruses which produce insect-specific paralytic neurotoxins and which display improved toxic effect on insects. Insect-toxic compositions are also provided. Methods of insect control using these neurotoxin genes, methods for production of neurotoxins in cells, and methods of production of insect control agents are described.

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