Insect sodium channels gene from insecticide-susceptible and ins

Details Insect sodium channels gene from insecticide-susceptible and ins Insect sodium channels gene from insecticide-susceptible and ins

1996-12-24

2000-02-08

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435348, 435455, 435475, 536 231, 536 235, C12N 1512, C12N 1585, C12N 1586, C07H 2104

Patent

active

060227052

ABSTRACT:
The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide susceptibility or insecticide resistance to Musca domestica, as well as to the isolated voltage-sensitive sodium channels of Musca domestica encoded thereby. Nucleic acid molecules encoding insecticide susceptible VSSCs and nucleic acid molecules encoding insecticide resistant VSSCs are provided. Methods for increasing or decreasing the expression of functional voltage-sensitive sodium channels in host cells are also provided, as well as methods using the sodium channels. Also provided is a method for isolating other voltage-sensitive sodium channels.

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