Insect retinoid-like receptor compositions and methods

Details Insect retinoid-like receptor compositions and methods Insect retinoid-like receptor compositions and methods

1995-06-05

1997-06-24

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530350, C12P 2106, C12N 500, C07K 100

Patent

active

056416520

ABSTRACT:
The present invention relates to the discovery of novel insect receptor polypeptides, which, when complexed with certain ligands, or otherwise activated by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with the promoters of the genes. The novel receptors of the invention are substantially similar to previously discovered mammalian receptors which are activated to modulate transcription of certain genes in cells, when the cells are exposed to retinoic acid. The invention provides DNAs encoding the novel receptors, including expression vectors for expression of the receptors in cells; cells transformed with such expression vectors; cells co-transformed with such expression vectors and with reporter vectors to monitor activation of the receptors to modulate transcription, when the cells are exposed to ligand for the invention receptor; and methods of using such co-transformed cells in screening for compounds which are capable of leading to activation of the receptors and for compounds which are capable of interfering with such activation and, as such, are potentially potent insecticides. The invention also provides DNA and RNA probes for identifying DNA's encoding related receptors, of insects and other animals, of the class, to which the novel receptors of the invention belong.

REFERENCES:
patent: 4880941 (1989-11-01), Shroot et al.
patent: 4981784 (1991-01-01), Evans et al.
patent: 5149631 (1992-09-01), Shroot et al.
patent: 5171671 (1992-12-01), Evans et al.
patent: 5217867 (1993-06-01), Evans et al.
patent: 5260432 (1993-11-01), Takaku et al.
patent: 5262300 (1993-11-01), Evans et al.
patent: 5274077 (1993-12-01), Evans et al.
patent: 5310662 (1994-05-01), Evans et al.
patent: 5312732 (1994-05-01), Evans et al.
patent: 5317090 (1994-05-01), Blaudin De The et al.
patent: 5376530 (1994-12-01), De The et al.
patent: 5403925 (1995-04-01), Ozato
patent: 5468617 (1995-11-01), Blaudin De The et al.
Heyman et al. (1992) Cell 68:397-406.
Hamada et al. (1989) Proc. Nat. Acad. Aci. USA 86:8289-93.
Wang et al. (1989) Nature 340:163-166.
Henrich et al. (1990) Nucl. Acids Res. 18:4143-48.
Mangelsdorf et al. (1990) Nature 345:224-229.

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