Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-10-23
2007-10-23
Belyavskyi, Michail A. (Department: 1644)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069100, C435S069300, C435S071100, C530S350000, C530S412000
Reexamination Certificate
active
10148565
ABSTRACT:
The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. The proteins with folds that do not occur naturally have a reduced IgE reactivity or allergenity and can therefore be used as therapeutic agents in the immunotherapy of allergies.
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Forster et al., “Natural and Recombinant Enzymatically Active or Inactive bee venom Phospholipase A2 has the same Potency to Release Histamine from Basophils in Patients with Hymenoptera Allergy”, The Journal of Allergy and Clinical Immunology, vol. 95, pp. 1229-1235, 1995.
Soldatova, et al., “Superior Biologic Activity of the Recombinant bee venom Allergen Hyaluronidase Expressed in Baculovirus-Infected Insect Cells as Compared withEscherichia coli”, The Journal of Allergy and Clinical Immunology, vol. 101, pp. 691-698, 1998.
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Cromwell Oliver
Fiebig Helmut
Suck Roland
Belyavskyi Michail A.
Merck Patent GmbH
Millen White Zelano & Branigan P.C.
Rooney Nora M.
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