Insect inhibitory lipid acyl hydrolases

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Reexamination Certificate

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Details

C435S195000, C435S197000, C536S023200

Reexamination Certificate

active

07662372

ABSTRACT:
The present invention discloses DNA sequences encoding plant and novel lipid acyl hydrolase proteins having coleopteran specific insect inhibitory activity, as well as variants and permuteins having enhanced levels of activity directed to controlling coleopteran insect infestation and enhanced levels of expression in planta. Additionally, catalytic dyad active site conformation is disclosed for both dicot and monocot plant derived non-specific lipid acyl hydrolases having coleopteran insect inhibitory properties.

REFERENCES:
patent: 5743477 (1998-04-01), Walsh et al.
patent: 5824864 (1998-10-01), Fox et al.
patent: 6339144 (2002-01-01), Cigan et al.
patent: 6657046 (2003-12-01), Alibhai et al.
patent: WO 98/54327 (1998-12-01), None
Dessen et al., Crystal Structure of Human Cytosolic Phospholipase A2Reveals a Novel Topology and Catalytic Mechanism,Cell 97:349-360 (1999).

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