Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-05-30
1997-10-07
LeGuyader, John L.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4351723, 435196, 4353201, 435348, 536 232, 536 235, A01N 6300, C12N 1585
Patent
active
056744854
ABSTRACT:
A recombinant expression vector is provided that is capable of expression in a host insect and includes a coding sequence for juvenile hormone esterase that, when expressed, lacks the signal sequence targeting the enzyme to the plasma membrane, and thus the resulting protein is cytoplasmic and non-glycosylated. Recombinant microbe embodiments have improved insecticidal activity because the modified, or truncated, protein builds up in microbe-infected cells within the insect and reduces the time taken for the microbe to kill the host.
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Hammock Bruce D.
Reilly Linda M.
LeGuyader John L.
The Regents of the University of California
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