Insect chymotrypsin and inhibitors thereof

Details Insect chymotrypsin and inhibitors thereof Insect chymotrypsin and inhibitors thereof

2004-04-23

2008-12-09

Moore, William W (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Plant proteins, e.g., derived from legumes, algae or...

C435S069200, C435S252300, C435S320100

Reexamination Certificate

active

07462695

ABSTRACT:
The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut ofHelicoverpa armigeraandHelicoverpa punctigerainsect larvae when fed the serine proteinase inhibitors ofNicotiana alata.The novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control ofHelicoverpaspp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity.

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