Inosose derivatives, production and use thereof

Details Inosose derivatives, production and use thereof Inosose derivatives, production and use thereof

1987-08-31

1990-02-06

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568 43, 568413, 564258, 564462, 564374, 564381, 564382, 564383, 564384, 564385, 564386, 564389, 564391, 564392, 549 20, 549 22, 549 35, 549 37, C07C 49497

Patent

active

048989860

ABSTRACT:
Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen.
The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.

REFERENCES:
patent: 4486602 (1984-12-01), Horii et al.
patent: 4777294 (1988-10-01), Horii et al.

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