Inorganic resins for clinical use of 213 Bi generators

Details Inorganic resins for clinical use of 213 Bi generators Inorganic resins for clinical use of 213 Bi generators

2011-03-29

2011-03-29

Hartley, Michael G (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

C424S001650

Reexamination Certificate

active

07914766

ABSTRACT:
Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.

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