Injectable solution containing a pyridyl methylsulfinylbenzimida

Details Injectable solution containing a pyridyl methylsulfinylbenzimida Injectable solution containing a pyridyl methylsulfinylbenzimida

1992-08-04

1993-06-29

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514669, 514723, 514925, 546199, A61K 31445, A61K 3113, A61K 3108

Patent

active

052235157

ABSTRACT:
An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group; R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, is provided by dissolving the compound in at least one of ethanol, propylene glycol and polyethylene glycol; or by dissolving the freeze-dried material of an alkaline aqueous solution of the compound in a mixture of an acidic substance and at least one of the above solvents.

REFERENCES:
patent: 4337257 (1982-06-01), Junggren et al.
patent: 4359465 (1982-11-01), Ruwart
patent: 4472409 (1984-09-01), Senn-Bilfinger
patent: 4554280 (1985-11-01), Krasso et al.
patent: 4555518 (1985-11-01), Rainer
patent: 4689333 (1987-08-01), Nohara et al.
patent: 4746667 (1988-05-01), Carlsson et al.
CA105:133883y Nohara et al. Pyridylmethylthio benzimidazdes and their Sulfoxides 1986.
U.S. Merck Index (#5945 & 7644) 9th Edition (1976).
U.S. Pharmacopeiz (1980) pp. 464-465.

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