Injectable ready-to-use solutions containing an antitumor anthra

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 64, A61K 3170

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active

049468316

ABSTRACT:
According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and which has a pH of from 2.5 to 6.5. The solution of the invention is particularly advantageous for the administration by injection of the anthracycline glycoside drugs, e.g. doxorubicin, in the treatment of both human and animal tumors.

REFERENCES:
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 4039663 (1977-08-01), Arcamone et al.
patent: 4058519 (1977-11-01), Arcamone et al.
patent: 4067969 (1978-01-01), Penco et al.
patent: 4077988 (1978-03-01), Arcamone et al.
patent: 4177264 (1979-12-01), Wu et al.
patent: 4325947 (1982-04-01), Penco et al.
patent: 4438105 (1984-03-01), Suarato et al.
Andrew G. Bosanquet, Stability of Solutions of Antineoplastic . . . , Cancer Chemother Pharmacol. (1986) 17:1-10.
F. Arcamone, et al., Structure and Physicochemical Properties . . . , International Symposium on Adriamycin (1972) 9-22.
J. H. Beijnen, et al, Stability of Antracycline Antitumour . . . , Research Article, vol. 39, No. 6, Nov.-Dec. (1985) 220-222.
Teresa Kaniewska, Badanie Rozkladu Adriamycyny, Farmacja Polsaka, XXXIII, 9, (1977), 539-542.
Guiragos K. Poochikian, et al., Stability of Anthracycline Antitumor Agents . . . , American Journal of Hospital Pharmacy, vol. 38, (Apr. 1981, 483-486.
J. H. Beijnen, et al., Aspects of the Chemical Stability . . . , Pharmaceutisch Weekblad Scientific Edition, vol. 7-1985, 109-116.
Dennis M. Hoffman, et al., Stability of Refrigerated and Frozen Solutions . . . , American Journal of Hospital Pharmacy, vol. 36(1979) 1536-1538.
Staffan Eksborg, et al., Liquid Chromatography in Anticancer Drug . . . , Journal of Pharmaceutical & Biomedical Analysis, vol. 2, no. 2, (184) 297-303.
T. Masuike, et al., Determination of Adriamycin and Its Metabolites . . . , YKKZAJ: J.Pharm.Soc.Jpn. vol. 104, no. 6, (1984), 614-23.
M. J. H. Janssen, et al., Doxorubicin Decomposition on Storage . . . International Journal of Pharmaceutics, 23 (1985) 1-11.
Aristide Vigevani and Martin J. Williamson, Doxorubicin, Analytical Profiles of Drug Substances, vol. 9, Academic Press (1980), pp. 244-274.
Karsten Wasserman and Hans Bundgaard, Kinetics of the Acid-Catalyzed Hydrolysis of Doxorubicin, International Journal of Pharmaceutics, 14 (1983) pp. 73-78.
Stability and Compatibility of Antitumor Agents in Glass and Plastic Containers, John A. Benvenuto, American Journal of Hospital Pharmacy, vol. 38.
Chemical Abstracts, vol. 104, No. 6, Feb. 10, 1986, p. 382 No. 39716d Columbus, Ohio & JP-A-60 92 212 (Kyowa Hakko Kogyo Co., Ltd.) 23-05-1985.
Int. J. of Pharmaceutics 31 (1986) 75-82, J. H. Beijnen et al.

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