Injectable ready-to-use solutions containing an antitumor anthra

Details Injectable ready-to-use solutions containing an antitumor anthra Injectable ready-to-use solutions containing an antitumor anthra

1990-01-25

1992-06-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3170

Patent

active

051243180

ABSTRACT:
A sealed glass container containing therein a stable, injectable, sterile, pyrogen-free doxorubicin anti-tumor composition in a solution which consists essentially of a physiologically acceptable salt of doxorubicin dissolved in a physiologically acceptable solvent therefor, wherein said solution has not been reconstructed from a lyophilizate, and wherein said solution has a pH of from 2.5-3.5 and a concentration of said doxorubicin of from 0.1 to 100 mg/ml.

REFERENCES:
patent: 4058519 (1977-11-01), Arcamone et al.
patent: 4075328 (1978-02-01), Ducep et al.
patent: 4109079 (1978-08-01), Henry et al.
patent: 4250303 (1981-02-01), Wu et al.
patent: 4296105 (1981-10-01), Baurain et al.
patent: 4675311 (1987-06-01), Gatti et al.
patent: 4946831 (1990-08-01), Gatti et al.
Berenuto et al., American Journal of Hospital Pharmacy, vol. 38, (1981), pp. 1914-1918.
Beijnen et al., Pharmaceutish, Weekblad Scientific Editor, vol. 7, (1985), pp. 109-116.
Arcamone et al., International Symposium on Adriamycin, (1972), pp. 9-22.
Boranquet, Cancer Chemother. Pharmacol., vol. 17, (1986), pp. 1-10.
English Translation of Official Action in Swedish Patent Application 8704849-2.
"Stability of Solutions of Antineoplastic Agents During Preparation and Storage for in Vitro Assays" by Andrew G. Bosanquet, pp. 1-10.
English Translation of Official Action issued in German Application, 3741037.7.
English Translation of Official Action in Swedish Patent Application 8602743-0.
"Kinetics of the Acid-Catalyzed Hydrolysis of Doxorubicin" by Karsten Wassermann et al.; pp. 73-78.
"Martindale--The Extra Pharmacopoeia", Twenty-eighth Edition, Edited by James E. F. Reynolds.
"Doxorubicin" by Aristide Vigevani et al.; pp. 246-274.
"Termical Degradation of Adriamycin Hydrochloride Substance and Solutions of Various pH were Examined, The Reaction Rate Constans, Temperature Factors and t.sub.10% were Determined" by Teresa Kaniewska.
"Aspects of the Chemical Stability of Doxorubicin and Seven Other Anthracyclines in Acidic Solution" by J. H. Beijnen et al.; pp. 109-116.
Journal of Parenteral Science and Technology, vol. 39, No. 6, 1985, pp. 220-222; by J. H. Beijnen et al.
The Merck Index, 10th Edition, 1983, p. 449, Edited by M. Windholz et al.
"Physicochemical Principles of Pharmacy" by A. T. Florence et al., Chemical Stability of Drugs, p. 475.
"The Merck Index", 10th Edition, by Martha Windholz et al., published by Merck & Co., Inc., Rahway, N.J., U.S.A., 1983; p. 499.

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