Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1998-07-31
1999-10-05
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
A61K 3105
Patent
active
059625368
ABSTRACT:
The invention provides injectable formulations of propofol using N-methylpyrrolidone or 2-pyrrolidone as a solvent. Formulations of the invention are useful in all medical and veterinary indications when propofol is presently used. In addition, combinations of propofol and an appropriate toxin are useful for fast-acting, humane, veterinary euthanasia injectable compositions. N-methylpyrrolidone-propylene glycol formulations are inherently bacteriostatic, thereby eliminating one of the problems associated with currently available formulations.
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patent: 5446070 (1995-08-01), Mantelle
patent: 5496537 (1996-03-01), Henry
patent: 5707996 (1998-01-01), Parrinello
Tonner, P.H. et al. "The General Anesthetic Potency of Propofol and Its Dependence on Hydrostatic Pressure"; (1992) Anesthesiology 77:926-931.
Advertising brochure for Nuflor.RTM. (Florfenicol) Injectable Solution; "Heads Up Therapy for BRD" published (1996) by Schering Corporation U.S.A.
Driscoll, D.F. et al., "Particle Size Distribution of Propofol Injection Ampules and Vials: The Benefits of Filtration"; (1997) Int. J. or Pharm. Compounding 1(2).
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