Injectable propofol formulations

Details Injectable propofol formulations Injectable propofol formulations

1998-07-31

1999-10-05

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

A61K 3105

Patent

active

059625368

ABSTRACT:
The invention provides injectable formulations of propofol using N-methylpyrrolidone or 2-pyrrolidone as a solvent. Formulations of the invention are useful in all medical and veterinary indications when propofol is presently used. In addition, combinations of propofol and an appropriate toxin are useful for fast-acting, humane, veterinary euthanasia injectable compositions. N-methylpyrrolidone-propylene glycol formulations are inherently bacteriostatic, thereby eliminating one of the problems associated with currently available formulations.

REFERENCES:
patent: 4772460 (1988-09-01), Malook
patent: 5446070 (1995-08-01), Mantelle
patent: 5496537 (1996-03-01), Henry
patent: 5707996 (1998-01-01), Parrinello
Tonner, P.H. et al. "The General Anesthetic Potency of Propofol and Its Dependence on Hydrostatic Pressure"; (1992) Anesthesiology 77:926-931.
Advertising brochure for Nuflor.RTM. (Florfenicol) Injectable Solution; "Heads Up Therapy for BRD" published (1996) by Schering Corporation U.S.A.
Driscoll, D.F. et al., "Particle Size Distribution of Propofol Injection Ampules and Vials: The Benefits of Filtration"; (1997) Int. J. or Pharm. Compounding 1(2).

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