Injectable opacifying composition containing liposomes of high e

Details Injectable opacifying composition containing liposomes of high e Injectable opacifying composition containing liposomes of high e

1995-05-12

1997-05-06

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

X-ray contrast imaging agent

424 9452, 424 9454, 424 945, A61K 4900

Patent

active

056268327

ABSTRACT:
Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.

REFERENCES:
patent: 3957971 (1976-05-01), Oleniacz
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4241046 (1980-12-01), Papahadjopoulos et al.
patent: 4529561 (1985-07-01), Hunt et al.
patent: 4567034 (1986-01-01), Charles et al.
patent: 4599227 (1986-07-01), Dees et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4744989 (1988-05-01), Payne et al.
patent: 5312615 (1994-05-01), Schneider et al.
patent: 5445810 (1995-08-01), Schneider et al.
"Radiopaque Liposomes for Imaging of the Spleen and Liver", Rozenberg, vol. 149, No. 3, Dec. 1983.
Liposome Disposition In Vivo, Abra et al., Biochimica et Biophysica Acta, 666 (1981) pp. 493-503.
Procedures for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Phase Evaporation, Szoka et al. (1978), pp. 4194-4198.
Chemical Abstracts (106:125855W) 1987.
Preparation of Liposomes of Defined Size Distribution By Extrusion Through Polycarbonate Membranes Olson et al., Biochimica et Biophysica Acta 557 (1979), pp. 9-23.
Size and Permeability of Lipsomes Extruded Through Polycarbonate Membranes, Morii et al., International Journal of Pharmaceutics, (1983), pp. 215-224.
Preparation of Unilamellar Liposomes of Intermediate Size (0.1-0.2.alpha.m) by a Combination of Reverse Phase, Szoka, Evaporation and Extrusion Through Polycarbonate Membranes, Biochimica et Biophysica Acta, 601 (1980), pp. 559-571.
Liposome Dialysis for Improved Size Distribution, Bosworth et al., Journal of Pharmaceutical Sciences, vol. 71, No. 7, Jul. 1982, pp. 806-812.
Liposome Filtration, Dependence on Transition Temperature, Brendzel et al., Biochima et Biophysica Acta 596 (1980), pp. 129-136.
Materials Properties of Liposomal Bilayers, Gruner, Princeton University, Princeton, New Jersey (1987).

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