Injectable microfoam containing a sclerosing agent

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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C424S422000, C424S484000

Reissue Patent

active

RE038919

ABSTRACT:
Injectable microfoam for sclerotcraphy. The sclerotherapy of varices is based on the injection of liquid substances capable of suppressing them. The present invention relates to the preparation of sclerosing substances in the form of a microfoam. The microfoam is prepared with sclerosing agents, and is then injected in the vein to be treated, so that the microfoam displaces the blood contained in the vein and provides for the contact of the sclerosing agent with the vascular endothelium, with a predetermined known concentration and during a controllable time.

REFERENCES:
patent: 3698453 (1972-10-01), Morane et al.
patent: 3970219 (1976-07-01), Spitzer et al.
patent: 4019657 (1977-04-01), Spitzer et al.
patent: 4040420 (1977-08-01), Speer
patent: 4127131 (1978-11-01), Vaillancourt
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4292972 (1981-10-01), Pawelchak et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4718433 (1988-01-01), Feinstein
patent: 5064103 (1991-11-01), Bennett
patent: 5084011 (1992-01-01), Grady
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5542935 (1996-08-01), Unger et al.
patent: 5623085 (1997-04-01), Gebhard et al.
patent: 5656200 (1997-08-01), Boettcher et al.
patent: 5676962 (1997-10-01), Garrido et al.
patent: 5902225 (1999-05-01), Monson
patent: 6561237 (2003-05-01), Brass et al.
patent: 1 232 837 (1988-02-01), None
patent: 3048744 (1982-07-01), None
patent: 3050812 (1985-03-01), None
patent: 8704600.8 (1987-11-01), None
patent: 3417182 (1989-01-01), None
patent: 69418286 (1999-10-01), None
patent: 0 054 728 (1982-06-01), None
patent: 0 077 752 (1983-04-01), None
patent: 0 123 235 (1984-10-01), None
patent: 0 131 540 (1985-01-01), None
patent: 0 217 582 (1987-04-01), None
patent: 324938 (1989-07-01), None
patent: 0 324 938 (1989-07-01), None
patent: 0 359 246 (1990-03-01), None
patent: 0 656 203 (1995-06-01), None
patent: 0 997 396 (2000-05-01), None
patent: 2 068 151 (1995-04-01), None
patent: 1 547 768 (1968-11-01), None
patent: 2 672 038 (1992-07-01), None
patent: 2 775 436 (1999-09-01), None
patent: WO 92/05806 (1992-04-01), None
patent: WO 95/00120 (1995-01-01), None
patent: WO 96/25194 (1996-04-01), None
patent: WO 99/43371 (1999-09-01), None
patent: WO 00/24649 (2000-05-01), None
patent: WO 00/66274 (2000-11-01), None
patent: WO 00 72821 (2000-12-01), None
Jan-Christoph G.R. Wollmann, MD, “The History of Sclerosing Foams”, Dermatol Surg. vol. 30, No. 5, pp. 694-703, May 2004.
German Nullity Action; English Translation of the Reply to appeal dated Feb. 12, 2004.
DVD #1 and #2 containing video clips shown during interview of Jan. 7, 2004.
Written commentary tracking the DVDs submitted herein.
R. Bayeux, “Comparative Resistance of Dog and Rabbit to Intravenous Injection of Oxygen”, Compt. Rend. vol. 156, pp. 1329-1331, 1913, with Abstract in English.
F.W. Runnicliffe et al., “The Intravenous Injection of Oxygen Gas as a Therapeutic Measure”, Lancet, vol. II, pp. 321-323, 1916, with Abstract in English.
G. Galata, “Intravenous Injection of Oxygen in Dogs”, Archivio di Fisiologia, vol. 21, pp. 331-350, 1923, with Abstract in English.
E.J. Orbach, “Schlerotherapy of Varicose Veins”, American Journal of Surgery, vol. LXVI, No. 3, pp. 362-366, Dec. 1944.
R. E. Weston et al., “The Influence of Denitrogenation on the Response of Anesthetized Dogs to Intravenously Injected Oxygen”, vol. 26, pp. 837-848, 1946.
A. Lemaire et al., “Effect of Intra-arterial oxygen injection on blood cholesterol”, Therapie, vol. 13, pp. 395-399, 1958, with Abstract in English.
V. Gorisch et al., “Expiration of labeled oxygen after intravenous insufflation”, Medicina Experimentalis, vol. 1, pp. 333-338, 1959, Abstract in English.
V. Gorisch et al., “Appearance of intravenously given radioactive oxygen in expired air”, Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie, vol. 238, pp. 106-107, 1960, with Abstract in English.
I. Singh, “Life Without Breathing”, Arch. int. Pharmacodyn., vol. CXXXVII, No. 3-4, pp. 318-330, 1962.
E. J. Orbach, “The Place of Injection Therapy in the Treatment of Venous Disorders of the Lower Extremity—with Comments on its Technique”, Presented at the Annual Meeting of the International College of Angiology, London, pp. 18-23, Jul. 1965.
S. Efuin et al., “Oxygen Parameters of Blood and Tissues during Intravascular Oxygenation of the Organism”, Eksperimental'naya Khirurgiya I Anesteziologiya, vol. 5, pp. 183-186, 1974, with Abstract in English.
B. Ya Varshavskii, “Mechanism of Changes in Renal Activity Following intravenous oxygen”, vol. 53, No. 2, pp. 173-177, 1967, with Abstract in English.
S. Efuin et al., Oxygen Parameters of Blood and Tissues during Intravascular Oxygenation of the Organism, Eksperimental'naya Khirurgiya I Anesteziologiya, vol. 5, pp. 71-74, 1974, with Abstract in English.
F.B. Cockett, “Arterial Complications during Surgery and Sclerotherapy of Varicose Veins”, Phlebology, vol. 1, pp. 3-6, 1986.
L. Karmazsin et al., “Experimental Study of Lipid Peroxidation Following Intravenous Oxygen”, Kiserletes Orvostudomany, vol. 39, pp. 342-348, 1987, with Abstract in English.
R. M. Knight et al., “Ultrasonic Guidance of Injections into the Superficial Venous System”, Phlebology, pp. 339-341, 1989.
Z.B. Shafi et al., “Factors Affecting High Shear Preparation of Albumin Microspheres”, Pharmaceutical Sciences Research GRoup, p. 144P, 1990.
G. Miserey et al., “Sclerose Sous Echographie Dans Certaines Zones a Risques”, Phlebologie, vol. 44, No. 1, pp. 85-96, 1991.
M. Schadeck et al., “Echotomographie de la Sclerose”, Phlebologie, vol. 44, No. 1, pp. 111-130, 1991.
R. de Somer-Leroy et al., “Echographie du Creux-Poplite Recherche D'Une Arteriole Petite Saphene Avant Sclerotherapie”, Phlebologie, vol. 44, No. 1, pp. 69-78, 1991.
Vin, “Echo-Sclerotherapy of the Small Saphenous Vein”, Phlebologie, vol. 44, No. 1, pp. 79-84, 1991 with Abstract in English.
P. Thibault et al., “Recurrent Varicose Veins”, Phlebology, vol. 18, pp. 895-900, 1992.
K. Biegeleisen et al., “Inadvertent Intra-Arterial Injection Complicating Ordinary and Ultrasound-Guided Sclerotherapy”, Phlebology, vol. 19, pp. 953-958, 1993.
German Nullity Action Complaint filed Jul. 27, 2001 and translation into English.
German Nullity Action First Brief filed Dec. 3, 2001 and translation into English.
German Nullity Action Supplemental Brief filed Dec. 31, 2002 and translation into English.
German Nullity Action Kreusler Brief filed Jan. 27, 2003 and translation into English.
German Nullity Action Decision by German Court in English dated Feb. 4, 2003.
German Nullity Action English Translation of the Substantiation of Appeal to the Federal Court of Justice on Sep. 26, 2003.
K1—Von P. Flückiger, “Nicht-operative retrograde Varicenverödung mit Varsylschaum”, Schweizerische Medizinische Wochenschrift, No. 48, pp. 1368-1370, (1956) with English translation.
K2—H. Mayer et al., “On the aetiology and treatment of varices of the lower extremities”, Angiology, Chirurgische Praxis, pp. 521-528, (1957) with English translation.
K3—Meyers'Encyclopedia, 5thEdition, vol. 15, pp. 386 (1985) with English translation.
K4—Von P. Flückiger et al., “Beitrag sur Technik der ambulanten Varizenbehandlung”, No. 12, pp. 617-621, Mar. 23, 1963.
K5—Dr. Med. Jo{hacek over (z)}e Baridevic; “Varicosclerozation in Phlebological Practice”; The Journal for Doctors, in Clinical and Practice; XXI vol. No. 3, pp. 126-136; Jan. 11, 1989, and translation into English.
K6—W. Gillesberger; “The Equipment of the Dermatologist Working in the Field of Phlebology”, the Journal for Skin Diseases; vol. 44 (18), pp. 669-674; 1969 and translatio

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