Injectable mesna solutions

Details Injectable mesna solutions Injectable mesna solutions

1995-06-07

1998-03-17

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

514709, 424 10, A61K 31095, A61K 3110, A61K 4900

Patent

active

057287384

ABSTRACT:
Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.

REFERENCES:
patent: 4720379 (1988-01-01), Heyl et al.
Corn et al., "Bioavailability of subcutaneous Ifosfamide and feasibility of continuous outpatient application in cancer patients", Anals of Oncology, vol. 1, pp. 365-368, 1990.
Kwon et al., "Activation Mechanisms of Mafosfamide and the Role of Thiols in Cyclophosphamide Metabolism", J. Med. Chem. 1987, vol. 30, pp. 395-399.
Leeuwenkamp, et al., "Reaction Kinetics of Cisplatin and its Monoaquated Species with the Modulating Agents (Di)mesna and Thiosulphate", Eur. J. Cancer, vol. 27, No. 10, pp. 1243-1247, 1991.

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