Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1988-07-18
1990-10-16
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514922, A61K 2700
Patent
active
049633457
ABSTRACT:
An injectable antidote for local anesthetic is disclosed. In the preferred and illustrated embodiment, it is a liquid injectable having a relatively low pH typically in the range of about 2.0 to as high as about 5.5, the preferred being about 3.5. It incorporates a biologically acceptable buffering system as for example lactic acid and a suitable salt thereof such as potassium or sodium. The system also preferably includes calcium, one form being calcium lactate. A target pH is about 3.5 for this system. In addition, a vasodilator is preferably included, and alternate additional constituents are a metabolizing agent for ester based anesthetics, and also for amide based anesthetics.
REFERENCES:
patent: 2268915 (1939-05-01), Wastl et al.
patent: 2919228 (1959-12-01), Luduena
Facts and Comparisons, p. 700, (Feb. 1988 Update).
Dorlands Illustrated Medical Dictionary; 25th Ed. (1974), p. 1200.
Principles of Medicinal Chemistry, 2nd Ed. (1981), pp. 416-417.
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