Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1998-08-13
2000-11-28
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
264 41, 264 433, 264 47, 42840221, A61K 950, B01J 1302, B32B 516
Patent
active
061532258
ABSTRACT:
Described are an injectable formulation of nanoparticulate naproxen that produces minimal or no pain or burning sensation upon administration, and methods of making and using such a formulation. The injectable formulation comprises nanoparticulate naproxen having a povidone polymer adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 600 nm.
REFERENCES:
patent: 3904682 (1975-09-01), Fried et al.
patent: 4009197 (1977-02-01), Fried et al.
patent: 4780320 (1988-10-01), Baker
patent: 4888178 (1989-12-01), Rotini et al.
patent: 4919939 (1990-04-01), Baker
patent: 4940588 (1990-07-01), Sparks et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5200193 (1993-04-01), Radebaugh et al.
patent: 5354556 (1994-10-01), Sparks et al.
patent: 5462747 (1995-10-01), Radebaugh et al.
patent: 5480650 (1996-01-01), Marchi et al.
patent: 5510118 (1996-04-01), Bosch et al.
patent: 5770222 (1998-06-01), Unger et al.
The Merck Index, 10.sup.th Edition, pp. 920 (Merck & Co., Rahway, NJ, 1983).
American Family Physician, Mar. 1997.
Marsala et al., "Treatment of Acute Pain of Ureteral and Biliary Colic with Naproxen Sodium Administered by the Parenteral Route," Int. J. Clin. Pharmacol. Res., 6:495-500 (1986) (IM an IV injections of naproxen).
L. Kvarnes, "Naproxen Sodium Versus Pentazocine in Treating Postoperative Pain," Curr. Ther. Res., Clin. Exp., 46:259-268 (1989) (IM injections of naproxen).
The Merck Index, 10.sup.th Edition, pp. 1106 (Merck & Co., Rahway, NJ, 1983).
De Castro Lan
Lee Robert
Azpuru Carlos A.
Elan Pharma International Limited
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