Injectable cross-linked collagen implant material

Details Injectable cross-linked collagen implant material Injectable cross-linked collagen implant material

1984-10-22

1986-04-15

Kight, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

514773, 514801, 128DIG8, C08L 8906, A61L 1504

Patent

active

045826404

ABSTRACT:
Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous medium at a concentration of 0.1 to 10 mg/ml with glutaraldehyde under conditions that produce cross-linked collagen that when in suspension in physiological saline at a concentration of 35 mg/ml exhibits a shear viscosity whose log varies linearly with the log of the shear rate and is approximated by the formula

REFERENCES:
patent: 3949073 (1976-04-01), Daniels et al.
patent: 4140537 (1979-02-01), Luck et al.
patent: 4233360 (1980-11-01), Luck et al.
patent: 4424208 (1984-01-01), Wallace et al.
Schechter, I., et al, "Prolonged Retention of Glutaraldehyde-Treated Skin Homografts in Humans", Brit. Journal of Plas. Surg., (1975) 28, 198-202.

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