Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
2008-07-29
2008-07-29
Richter, Johann (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C514S037000, C514S039000, C514S152000
Reexamination Certificate
active
11088922
ABSTRACT:
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22fatty acid, and preferably may be a saturated or unsaturated C10-C18fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.
REFERENCES:
patent: 4298375 (1981-11-01), Howe et al.
patent: 4820695 (1989-04-01), Debono et al.
patent: 5574020 (1996-11-01), Klink et al.
patent: 5658956 (1997-08-01), Martin et al.
patent: 5723447 (1998-03-01), Macy et al.
patent: 5736152 (1998-04-01), Dunn
patent: 5747058 (1998-05-01), Tipton et al.
patent: 5958888 (1999-09-01), Macy et al.
patent: 6034070 (2000-03-01), Armbruster
patent: 6034175 (2000-03-01), Hutchinson
patent: 6074657 (2000-06-01), Brown
patent: 6110905 (2000-08-01), Patterson et al.
patent: 6174540 (2001-01-01), Williams et al.
patent: 6239112 (2001-05-01), Macy et al.
patent: 6310053 (2001-10-01), Patterson et al.
patent: 6328961 (2001-12-01), Cutrone et al.
patent: 6403057 (2002-06-01), Schneider et al.
patent: 6479473 (2002-11-01), Patterson et al.
patent: 6504005 (2003-01-01), Bridken et al.
patent: 6660278 (2003-12-01), Larsson et al.
patent: 6677321 (2004-01-01), Levin
patent: 6887487 (2005-05-01), Murthy et al.
patent: 6946137 (2005-09-01), Murthy et al.
patent: 2003/0130211 (2003-07-01), Murthy et al.
patent: 2003/0216447 (2003-11-01), Kohan et al.
patent: 2003/0219461 (2003-11-01), Britten et al.
patent: 2003/0220302 (2003-11-01), Kohan et al.
patent: 2004/0023899 (2004-02-01), Murthy et al.
patent: 2004/0033938 (2004-02-01), Britten et al.
patent: 2004/0057979 (2004-03-01), Wong et al.
patent: 2005/0163859 (2005-07-01), Murthy et al.
patent: 2-7314 (1982-07-01), None
International Search Report dated Apr. 23, 2003 for PCT International Application No. PCT/US02/33300.
Jordan, W.H., et al., “A Review of the Toxicology of the Antibiotic MICOTIL 300,”Vet. Hum. Toxicol. 35(2):151-158, Apr. 1993.
Watson, A.D.J., BVSc, PhD, et al., Chloramphenicol Toxicosis in Cats,American Journal of Veterinary Researchvol. 39, No. 7, Jul. 1978, pp. 1078, 1199 and 1200-1203.
Watson, A.D.J., BVSc, PhD, MRCVS, et al., Further Observations on Chloramphenicol Toxicosis in Cats,American Journal of Veterinary Research of the American Veterinary Medical Association, vol. 41, No. 2, Feb. 1980, pp. 157, 293-294.
Penny, R.H.C., et al., Effects of Chloramphenicol on the Haemopoietic System of the Cat,The British Veterinary Journal, vol. CXXIII, vol. 123, 1967, pp. 145-153.
Tuttle, Allison D., Dr., et al., Bone Marrow Hypoplasia Secondary to Florfenicol Toxicity in a Thomson's Gazelle (Gazella Thomsonii),Journal of Veterinary Pharmacology and Therapeutics, vol. 29, Aug. 2006, pp. 317-319.
Doherty, M. L. et al., “Combined oxyteracycline-flunixin Therapy in Field Cases of Acute Bovine Respiratory Disease,”Irish Veterinary Journal, 54(5), May 2001, 232-238.
Niece, K. L. et al., “Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction,”J. Am. Chem. Soc., 2003, 125, 7146-7147.
Murthy Yerramilli V.S.N.
Suva Robert H.
George Konata M
Idexx Laboratories
Richter Johann
Townsend and Townsend and Crew LLP.
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