Inhibitory peptides against .alpha.-2, .beta.-1 mediated mg.sup.

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530330, 514 14, 514 16, 514 17, 514 18, A61K 3102, C07K 708, C07K 510

Patent

active

051208300

ABSTRACT:
Novel short peptides are disclosed which are selected from the group consisting of GPAGKDGEAGAQG and fragments thereof containing the minimal sequence Ala Gly Glu Ala. These peptides have inhibitory activity against .alpha..sub.2 .beta..sub.1 -mediated Mg.sup.++ -dependent adhesion of platelets to collagen.

REFERENCES:
Staatz, et al, J. Biol. Chem. vol. 266, pp. 7363-7367, 1991.
Santoro et al., Biochem. Biophys. Res. Commun. 153, 217-223 (1988).
Kunick et al., J. Biol. Chem. 263, 4516-4519 (1988).
Staatz et al., J. Cell Biol. 108, 1917-1924 (1989).
Santoro, Cell 46, 913-920 (1986).
Coller et al., Blood 74, 182-192 (1989).
Wayner and Carter, J. Cell Biol. 105, 1873-1884 (1987).
Staatz et al., J. Biol. Chem. 265, 4778-4781 (1990).
Bornstein, Ann. Rev. Biochem. 49, 957-960 (1980).
Gulberg et al., J. Biol. Chem. 264, 12686-12694 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitory peptides against .alpha.-2, .beta.-1 mediated mg.sup. does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitory peptides against .alpha.-2, .beta.-1 mediated mg.sup., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitory peptides against .alpha.-2, .beta.-1 mediated mg.sup. will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1805289

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.