Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-06-10
1998-10-06
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241331, 4241521, 4241721, 435 71, 435 725, 435 721, 435 696, 435 7021, 4351713, 4353201, 435326, 435378, 435334, 536 2353, 5303873, 53038822, A61K 39395, C07K 1628, C07H 2102, G01N 3353
Patent
active
058173102
ABSTRACT:
The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
REFERENCES:
patent: 5268358 (1993-12-01), Fretti
patent: 5468468 (1995-11-01), La Rochelle et al.
Hedlin Transplant. Proc. 25: 2074-2076 (1993).
1. Kovacs Immunol Today 12: 17-23 (1991).
2. Meyer-Ingold Tibtech 11: 387-392 (1993).
1. Osband et al. Immunology Today 11: 193-195 (1990).
2. Dermer Biotechnology 12: 320 (1994).
3. Dillman J. Clin Oncol (1994).
4. Nilsson Exp Cell Res. 145: 231-237 (1983).
5. Pelligani et al. Cancer Immunol. Immuno Thera 34: 37-34 (1991).
6. Diugi et al. INCI 83: 97-104 (1991).
1. Smits et al. Am J Pathol 140 (3) 639-648 (1992) Abstract only.
2. Palman et al. Lab. Invest. 66: 108-115 (1992).
3. Palman et al. Lab Invest 67: 529-534 (1992).
4. Antoniades et al. PNAS 89: 3942-3946 (1992).
5. La Rochelle et al. Cell Growth & Differentiation.sub.-- :547-553 (1993).
6. Webdermank et al. 15:257-263 (1995).
Krane, et al., "Increased Dermal Expression of Platelet-Derived Growth Factor Receptors in Growth-Activated Skin Wounds and Psoriasis", The Journal of Investigative Dermatology, 96: 983-986 (1991).
Kawamoto et al., Monoclonal Antibodies to Epidermal Growth Factor Receptors in Studies of Receptor Structure and Function (1990), Cytotechnology 3:279-293.
Bellot et al., High-Affinity Epidermal Growth Factor Binding is Specifically Reduced by a Monoclonal Antibody, and Appears Necessary for Early Responses (1990), J. Cell Biol. 110:491-502.
Reilly et al., Monoclonal Antibodies Directed Against Basic Fibroblast Growth Factor Which Inhibit its Biological Activity In Vitro and In Vivo (1989), Biochem. Biophys. Res. Commun. 164:736-743.
Fendly et al., Characterization of Murine Monoclonal Antibodies Reactive to Either the Human Epidermal Growth Factor Receptor or HER2/Neu Gene Product (1990), Cancer Res. 50:1550-1558.
Ennis et al., Anti-Epidermal Growth Factor Receptor Antibodies Inhibit the Autocrine-Stimulated Growth of MDA-468 Human Breast Cancer Cells (1989), Mol. Endocrinol. 3:1830-1838.
Westermark et al., B-Type Receptor for Platelet-Derived Growth Factor Mediates a Chemotactic Response by Means of Ligand-Induced Activation of the Receptor Protein-Tyrosine Kinase (1990), Proc. Natl. Acad. Sci. USA 87:128-132.
Ferns et al., Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF (1991), Science 253:1129-1132.
Ronnstrand et al., Purification of the Receptor for Platelet-Derived Growth Factor from Porcine Uterus (1987), J. Biol. Chem. 262:2929-2932.
Claesson-Welsh et al., Identification and Structural Analysis of the A Type Receptor for Platelet-Derived Growth Factor (1989), J. Biol. Chem. 264:1742-1747.
Kawahara et al., Monoclonal Antibody C3.1 is a Platelet-Derived Growth Factor (PDGF) Antagonist (1987), Biochem. Biophys. Res. Commun. 147:839-845.
Claesson-Welsh et al., cDNA Cloning and Expression of the Human A-Type Platelet-Derived Growth Factor (PDGF) Receptor Establishes Structural Similarity to the B-Type PDGF Receptor (1989), Proc. Natl. Acad. Sci. USA 86:4917-4921.
Seifert et al., Two Different Subunits Associate to Create Isoform-Specific Platelet-Derived Growth Factor Receptors (1989), J. Biol. Chem. 264:8771-8778.
Lerner et al., Monoclonal Antibody YB5.B8 Identifies the Human C-Kit Protein Product (1991), Blood 77:1876-1883.
Heidaran et al., Chimeric .alpha.-and .beta.-Platelet-Derived Growth Factor (PDGF) Receptors Define Three Immunoglobulin-Like Domains of the .alpha.-PDGF Receptor that Determine PDGF-AA Binding Specificity (1990), J. Biol. Chem. 265:18741-18744.
Keating et al., Processing of the Platelet-Derived Growth Factor Receptor (1987), J. Biol. Chem. 262:7932-7937.
Daniel et al., Biosynthetic and Glycosylation Studies of Cell Surface Platelet-Derived Growth Factor Receptors (1987), J. Biol. Chem. 262:9778-9784.
Escobedo et al., Platelet-Derived Growth Factor Receptors Expressed by cDNA Transfection Couple to a Diverse Group of Cellular Responses Associated with Cell Proliferation (1988), J. Biol. Chem. 263: 1482-1487.
Hart et al., Synthesis, Phosphorylation, and Degradation of Multiple Forms of the Platelet-Derived Growth Factor Receptor Studied Using a Monoclonal Antibody (1987), J. Biol. Chem. 262:10780-10785.
Ronnstrand et al., Characterization of Two Monoclonal Antibodies Reactive with the External Domain of the Platelet-Derived Growth Factor Receptor (1988), J. Biol. Chem. 263:10429-10435.
Bishayee et al., Characterization of a Novel Anti-Peptide Antibody that Recognizes a Specific Conformation of the Platelet-Derived Growth Factor Receptor (1988), Mol. Cell. Biol. 8:3696-3702.
Kumjian et al., Platelet-Derived Growth Factor (PDGF) Binding Promotes Physical Association of PDGF Receptor with Phospholipase C. (1989), Proc. Natl. Acad. Sci. USA 86:8232-8236.
Pasquale et al., A Distinctive Family of Embryonic Protein-Tyrosine Kinase Receptors (1990), Proc. Natl. Acad. Sci. USA 87:5812-5816.
Eppstein et al., Inhibition of Epidermal Growth Factor/Transforming Growth Factor-.alpha.-Stimulated Cell Growth by a Synthetic Peptide (1989), J. Cell. Physiol. 141:420-430.
Kazlauskas et al., Phosphorylation of the PDGF Receptor .beta. Subunit Creates a Tight Binding Site for Phosphatidylinositol 3 Kinase (1990), EMBO J. 9:3279-3286.
Kanakaraj et al., Ligand-Induced Interaction Between .alpha.-and .beta.-Type Platelet-Derived Growth Factor (PDGF) Receptors: Role of Receptor Heterodimers in Kinase Activation (1991), Biochemistry 30:1761-1767.
Heldin et al., Binding of Different Dimeric Forms of PDGF to Human Fibroblasts: Evidence for Two Separate Receptor Types (1988), EMBO J. 7:1387-1393.
Ramakrishnan et al., A Novel Monoclonal Antibody Dependent on Domain 5 of the Platelet-Derived Growth Factor Beta Receptor Inhibits Ligand Binding and Receptor Activation (1993), Growth Factors 8:253-265.
Waldmann, Monoclonal Antibodies in Diagnosis and Therapy (1991), Science, 252:1657-1662.
Cunningham, Antibody Engineering--How to Be Human, TIBTECH, vol. 10 (1992) 10-11.
Williams, Signal Transduction by the Platelet-Derived Growth Factor Receptor (1992), Science, 243:1564-1570.
Queen et al., A Humanized Antibody that Binds to the Interleukin 2 Receptor (1989), Proc. Natl. Acad. Sci. USA, 86:10029-10033.
Harris et al., Therapeutic Antibodies--the Coming of Age (1993), TIBTECH, 11:42-44.
Escobedo Maria Amelia
Fretto Larry J.
Lokker Nathalie
Ramakrishnan Vanitha
COR Therapeutics Inc.
Feisee Lila
Gambel Phillip
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