Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2006-06-13
2006-06-13
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S130100, C424S133100, C424S141100, C424S152100, C424S172100, C530S387100, C530S387300, C530S388100, C530S388200, C530S388220
Reexamination Certificate
active
07060271
ABSTRACT:
The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) receptor activation as indicated by inhibition of receptor phosphorylation and dimerization, and by inhibition of PDGF-mediated mitogenesis, chemotaxis and migration of cells displaying the human PDGF type beta receptor on the cell surface. Nucleic acids encoding the immunoglobulin polypeptides are also included in the invention. The immunoglobulin polypeptides have diagnostic and therapeutic uses.
REFERENCES:
patent: 5268358 (1993-12-01), Fretto
patent: 5468468 (1995-11-01), La Rochelle et al.
patent: 5817310 (1998-10-01), Ramakrishnan et al.
patent: 327 369 (1989-02-01), None
patent: WO 90/07861 (1990-07-01), None
patent: WO 90/10013 (1990-09-01), None
patent: WO 92/13867 (1992-08-01), None
patent: WO 93/10805 (1993-06-01), None
patent: WO 93/11223 (1993-06-01), None
Matsui et al., Isolation of novel receptor cDNA establishes the existence of two PDGF receptor genes,Science(1989) 243:800-804.
Vasbotn et al., A monoclonal antibody against PDGF B-chain inhibits PDGF-induced DNA synthesis in C3H fibroblasts and prevents binding of PDGF to its receptor,Biochem. Biophys. Acta(1990) 1054:246-249.
Yarden et al. , Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors,Nature(1986) 323:226-232.
Antoniades et al., Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products (1992),Proc. Natl. Acad. Sci. USA89:3942-3946.
Bellot et al., High-Affinity Epidermal Growth Factor Binding is Specifically Reduced by a Monoclonal Antibody and Appears Necessary for Early Responses (1990),J. Cell Biol. 110:491-502.
Bishayee et al., Characterization of a Novel Anti-Peptide Antibody that Recognizes a Specific Conformation of the Platelet-Derived Growth Factor Receptor (1988),Mol. Cell. Biol. 8:3696-3702.
Claesson-Welsh et al., Identification and Structural Analysis of the A Type Receptor for Platelet-Derived Growth Factor (1989),J. Biol. Chem. 264:1742-1747.
Claesson-Welsh et al., cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor estabilshes structural similarity to the B-type PDGF receptor (1989),Proc. Natl. Acad. Sci. USA86:4917-4921.
Cunningham, Antibody Engineering—How to by Human (1992),Trends Biotechnol. 10:10-11.
Daniel et al., Biosynthetic and Glycosylation Studies of Cell Surface Platelet-Derived Growth Factor Receptors (1987),J. Biol. Chem. 161:9778-9784.
Dermer, Human cancer research (1983)Science221:318.
Dillman et al., Intensive chemotherapy with autologous peripheral-blood stem-cell rescue in metastatic breat cancer (1994),J. Clin. Oncol. 12:2237.
Divgi et al., Phase I and imaging trial of indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma (1991),J. Natl. Cancer Inst. 83:97-104.
Ennis et al., Anti-Epidermal Growth Factor Receptor Antibodies Inhibit the Autocrine-Stimulated Growth of MDA-468 Human Breast Cancer Cells (1989),Mol. Endocrinol.3:1830-1838.
Eppstein et al., Inhibition of Epidermal Growth Factor/Transforming Growth Factor-α-Stimulated Cell Growth by a Synthetic Peptide (1989),J. Cell. Physiol.141:420-430.
Escobedo et al., Platelet-Derived Growth Factor Receptors Expressed by cDNA Transfection Couple to a Diverse Group of Cellular Responses Associated with Cell Proliferation (1988),J. Biol. Chem. 263:1482-1487.
Fendly et al., Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2
eu gene product (1990),Cancer Res. 50:1550-1558.
Ferns et al., Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF (1991),Science253:1129-1132.
Harris et al., Therapeutic Antibodies—the Coming of Age (1993),Trends Biotechnol. 11:42-44.
Hart et al., Synthesis, Phosphorylation, and Degradation of Multiple Forms of the Platelet-Derived Growth Factor Receptor Studied Using a Monoclonal Antibody (1987),J. Biol. Chem. 262:107870-10785.
Heidaran et al., Chimeric α- and Bβ-Platelet-Derived Growth Factor (PDGF) Receptors Define Three Immunoglubulin-Like Domains of the α-PDGF Receptor that Determine PDGF-AA Binding Specificity (1990),J. Biol. Chem.265:18741-18744.
Heldin et al., Binding of Different Dimeric Forms of PDGF to Human Fibroblasts: Evidence for Two Separate Receptor Types (1988),EMBO J. 7:1387-1393.
Kanakaraj et al., Ligand-Induced Interaction Between α- and β-Type Platelet-Derived Growth Factor (PDGF) Receptors: Role of Receptor Hererodimers in Kinase Activation (1991),Biochemistry30:1761-1767.
Kawahara et al., Monoclonal Antibody C3.1 is a Platelet-Dervied Growth Factor (PDGF) Antagonist (1987),Biochem. Biophys. Res. Commun. 147:839-845.
Kawamoto et al., Monoclonal Antibodies to Epidermal Growth Reactor Receptors in Studies of Receptor Structure and Function (1990),Cytotechnology3:279-293.
Kazlauskas et al., Phosphorylation of the PDGF Receptor β Subunit Creates a Tight Binding Site for Phosphatidylinositol 3 Kinase (1990),EMBO J.9:3279-3286.
Keating et al., Processing of the Platelet-Derived Growth Factor Receptor (1987),J. Biol. Chem.262:7932-7937.
Kovacs, Fibrogenic cytokines: the role of immune mediators in the development of scar tissue (1991),Immunol. Today12:17-23.
Krane et al., Increased Dermal Expression of Platelet-Derived Growth Factor Receptors in Growth-Activated Skin Wound and Psoriasis (1991),J. Invest. Dermatol. 96:983-986.
Kumjian et al., Platelet-Derived Growth Factor (PDGF) Binding Promotes Physical Association of PDGF Receptor with Phospholipase C (1989),Proc. Natl. Acad. Sci. USA86:8232-8236.
LaRochelle et al., Inhibition of platelet-derived growth factor autocrine growth stimulation by monoclonal antibody to the human alpha platelet-derived growth factor receptor (1993),Cell Growth Differ. 4:547-553.
Lerner et al., Monoclonal Antibody YB5.B8 Identifies the Human C-Kit Protein Product (1991),Blood77:1876-1883.
Meyer-Ingold, Wound therapy: growth factors as agents to promote healing (1993),Trends Biotechnol. 11:3887-392.
Nilsson et al., Demonstration of stimulatory effects of platelet-derived growth factor on cultivated rat arterial smooth muscle cells. Differences between cells from young and adult animals (1983),Exp. Cell. Res. 145:231-237.
Osband et al., Problems in the investigational study and clinical use of cancer immunotherapy (1990),Immunol. Today11:193-195.
Palman et al., Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors (1992),Lab. Invest.66:108-115.
Pascuale et al., A Distinctive Family of Embryonic Protein-Tyrosine Kinase Receptors (1990),Proc. Natl. Acad. Sci. USA87:5812-5816.
Pellegrini et al., Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site (1991),Cancer Immunol. Immunother. 34:37-42.
Plate et al., Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas (1992),Lab. Invest. 67:529-534.
Queen et al., A Humanized Antibody that Binds to the Interleukin 2 Receptor (1989),Proc. Natl. Acad. Sci. USA, 86:10029-10033.
Ramakrishnan et al., A Novel Monoclonal Antibody Dependent on Domain 5 of the Platelet-Derived Growth Factor Beta Receptor Inhibits Ligand Binding and Receptor Activation (1993),Growth Factors8:253-265.
Reilly et al., Monoclonal Antibodies Directed Against Basic Fibroblast Growth Factor Which Inhibit Its Biological Activity In Vitro and In Vivo (1989),Biochem. Biophys. Res. Commun. 164:736-743.
Ronnstrand et al., Purification of the Receptor for Platelet-Derived Growth Factor from Porcine Uterus (1987),J. Biol. Chem. 262:2929-2932.
Ronnstrand e
Escobedo Maria Amelia
Fretto Larry J.
Ramakrishnan Vanitha
Gambel Phillip
Millennium Pharmaceuticals Inc.
Morgan & Lewis & Bockius, LLP
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