Inhibitory binding protein for insulin-like growth factors

Details Inhibitory binding protein for insulin-like growth factors Inhibitory binding protein for insulin-like growth factors

1992-10-22

1997-12-02

Walsh, Stephen

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 530399, 435 71, 435 721, C07K 14435, C07K 1465, G01N 33566

Patent

active

056937547

ABSTRACT:
The invention provides homogeneous compositions of a binding protein for insulin-like growth factors (IGFs) I and II, which binding protein inhibits the proliferative effects of IGF-I and IGF-II upon bone cells. The homogeneous protein of the invention is therefore known as inhibitory IGF binding protein, or In-IGF-BP. The invention also provides cloned nucleic acid sequences encoding In-IGF-BP, artificial expression systems for In-IGF-BP and host cells which produce useful quantities of In-IGF-BP. The invention further provides clinical diagnostic assays for IGFs, therapeutic treatments for IGF-responsive tumors, and means for modulating IGF activity upon bone cells.

REFERENCES:
Bell, et al., Nature 310: 775-777 (1984).
Canalis et al., J. Clin. Invest. 66: 709-719 (1980).
Mohan et al., Biochim. Biophys. Acta. 966: 4-55 (1988).
Arteaga et al., J. Clin. Invest. 84: 1418-1423 (1989).
El-Badry et al., J. Clin. Invest. 84: 829-839 (1989).
Forbes et al., Biochem. Biophys. Res. Commun. 157: 196-202 (1988).
Povoa et al., Eur. J. Biochem. 144: 199-204 (1984).
Koistinen et al., Endocrinology 118: 1375-1378 (1986).
Bell and Keyte, Endocrinology 123: 1202-1204 (1988).
Povoa et al., Biochem. Biophys. Res. Commun. 128: 1071-1078 (1985).
Brinkman et al., EMBO J. 7: 2417-2423 (1988).
Lee et al., Mol. Endocrinol. 2: 404-411 (1988).
Brewer et al., Biochem. Biophys. Res. Commun. 152: 1289-1297 (1988).
Julkumen et al., FEBS Lett. 236: 295-302 (1988).
Mottola et al., J. Biol. Chem. 261: 11180-11186 (1986).
Szabo et al., Biochem. Biophys. Res. Commun. 151: 207-214 (1988).
Brown et al., J. Biol. Chem. 264: 5148-5154 (1989).
Baxter et al., J. Biol. Chem. 264: 11843-11848 (1989).
Baxter and Martin, Proc. Natl. Acad. Sci. USA 86: 6898-6902 (1989).
Wood et al., Mol. Endocrinol. 2: 1176-1185 (1989).
Martin et al., J. Biol. Chem. 265: 4124-4130 (1990).
Mohan et al., Proc. Natl. Acad. Sci. USA 86: 8338-8342 (1989).

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