Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2011-03-29
2011-03-29
Kim, Jennifer M (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S558000, C562S400000
Reexamination Certificate
active
07915313
ABSTRACT:
The invention broadly relates to the use of α,β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to C15 α,β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.
REFERENCES:
patent: 2002/0086041 (2002-07-01), Maignan et al.
patent: 0 568 307 (1993-11-01), None
patent: 0 709 092 (1995-10-01), None
patent: 1149880 (2001-10-01), None
patent: 58-213716 (1983-10-01), None
English Translation (JP58213716) Dec. 12, 1983, Iwamura pp. 1-17.
Langner et al., 4-Oxatetradecanoic Acid Is Fungicidal for Cryptococcus neoformans and Inhibits Replication of Human Immunodeficiency Virus I, Journal of Biological Chemistry vol. 267 No. 24 (1992) pp. 17159-17169.
Wang et al., A Bacterial Cell-cell Communication Signal with Cross-kingdom Structural Analogues, Molecular Microbiology vol. 51(3) (2004) pp. 903-912.
Barber, et al., A novel regulatory system required for 20 pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule,. Mol Microbiol. (1997) 24(3):555-566.
Brown, Alistair J.P. and Neil A.R. Gow, Regulator networks controlling Candida albicans morphogenesis, Trends Microbiol. (1999) 7(8):333-338.
Brown, et al., Diastereoselective synthesis of tetrahydrofuran-containing fragments by the permanganate oxidation of 1, 5,9-trienes, Chem. Commun. (2000) 1735-1736.
Chiang, John Y.L., Bile acid regulation of gene expression : roles of nuclear hormone receptors, Endocrine Reviews (2002) 23(4):443-463.
Corner, Brian. E. and P.T. Magee, Candida pathogenesis : unraveling the threads of infection., Current Biology, (1997) 7(11):R691-R694.
Forman, et al., Identification of a nuclear receptor that is activated by farnesol metabolites, Cell (1995) 81:687-693.
Kim, et al., Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism, Bioorgic & Meicianl Chemistry Letters (2002) 12:895-898.
Liu, Haoping, Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen, Int. J. Med. Microbiol. (2002) 292, 299-311.
Madhani, H. D. and G.R. Fink, The control of filamentous differentiation and virulence in fungi, Trends Cell Biol (1998) 8, 348-353.
McGeady, et al., Carvone and perillaldehyde interfere with the serum-induced formation of filamentous structures in Candida albicans at substantially lower concentrations than those causing significant inhibition of growth, J. Nat. Prod (2002) 65:953-955.
Mittendorf et al., Novel antifungal beta-amino acids: synthesis and activity against Candida albicans, Bioorganic & Medicinal Chemistry Letters (2003) 13:433-436.
Navarro-Garcia, et al., Virulence genes in the pathogenic yeast Candida albicans, FEMS Microbial. Rev. (2001) 25:245-268.
Oh et al., Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans, Proc. Natl. Acad. Sci. U.S.A. (2001) 98(8):4664-4668.
Rappe, C., Org. Synth. (1973) 53:123-127.
Rappe, C. and R. Adestrom, Favorsky rearrangements IV. The preparation of some cis-cL, (3-unsaturated acids, Acta Chem Scand. (1965) 19:383-389.
Staib et al., Differential activation of a Candida albicans virulence gene family during infection, Proc. Natl Acad. Sci. U. S. A. (2000) 97(11):6102-6107.
Weinberger, C., A model for farnesoid feedback control in the mevalonate pathway, Trends Endocrinol. Metab. (1996) 7(1):1-6.
Dow et al., Biofilm dispersal in Xanthomonas campestris is controlled by cell-cell signaling and is required for full virulence to plants, Proc. Natl Acad. Sci. USA, (2003) 100(19):10995-11000.
Cason, James and C. Freeman Allen, “Synthesis and Properties of L(+)-2,4-Dimethyl-2-Dodecenoic Acid”, Journal of Biological Chemistry, 205:449-457 (1953).
Chhabra et al., “Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone and Immune Modulators”, J. Med. Chem., 46:97-104 (2003).
Hornby et al., “Quorum Sensing in the Dimorphic Fungus Candida albicans in Mediated by Farnesol”, Applied and Environmental Microbiology, 67:2982-29992 (2001).
Shchepin et al., “Quorum Sensing in Candida albicans: Probing Farnesol's Mode of Action with 40 Natural and Synthetic Farnesol Analogs”, Chemistry & Biology, 10:743-750 (2003).
Wang Lian-Hui
Zhang Lian-Hui
Agency for Science Technology and Research
BioTechnology Law Group
Kim Jennifer M
Whittaker Michael A.
LandOfFree
Inhibitors of yeast filamentous growth and method of their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of yeast filamentous growth and method of their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of yeast filamentous growth and method of their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2629699