Inhibitors of αLβ2 mediated cell adhesion

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S256000, C546S273100, C546S121000, C548S302700, C548S302100, C514S338000, C514S387000, C544S238000

Reexamination Certificate

active

06897225

ABSTRACT:
The present invention relates to a compound of the following formula:or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating αLβ2adhesion mediated conditions in a mammal.

REFERENCES:
patent: A-8287587 (1988-06-01), None
patent: WO 9839303 (1998-09-01), None
patent: WO 9858947 (1998-12-01), None
patent: 99 10312 (1999-03-01), None
Chalmers (TiPS vol. 17, pp. 166-172 Apr. 1996).*
Dyatkin, Tetrahedron Letters, vol. 38, No. 12, pp. 2065-2066 (1997).
Kelly et al., J. Immunol., vol. 163, No. 10, pp. 5173-5177 (1999).
Biano et al., J. org. Chem., vol. 65, No. 7, pp. 2179-2187 (2000).

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