Inhibitors of trypsin-like enzymes

Details Inhibitors of trypsin-like enzymes Inhibitors of trypsin-like enzymes

1998-05-14

2000-09-05

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 514 17, 514 19, 530330, 530331, A61K 3800, C07K 500, C07K 1600

Patent

active

061143081

ABSTRACT:
Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X.dbd.H or is an N-protecting group; Y is 1-10 .alpha.-amino acids; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4, alkyl; and the asymmetric carbon atom marked * may have the D- or L-configuration, are useful in therapeutic methods of inhibiting thrombin.

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patent: 5648338 (1997-07-01), Kakkar et al.
Bajusz et al., "Inhibition of Thrombin and Trypsin by Tripeptided Aldehydes," Int. J. Peptide and Protein Res., 12:217-221 (1978).
Chang, "Thrombin specificity," Eur. J. Biochem., 151:217-224 (1985).

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