Inhibitors of trypsin-like enzymes

Details Inhibitors of trypsin-like enzymes Inhibitors of trypsin-like enzymes

1994-05-10

1996-11-12

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 530330, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

055740146

ABSTRACT:
Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X=H or is an N-protecting group; Y is Phe-Pro; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L- configuration, are useful in therapeutic methods of inhibiting thrombin.

REFERENCES:
patent: 4428874 (1984-01-01), Svendsen
patent: 4450105 (1984-05-01), Nagasawa et al.
patent: 4638047 (1987-01-01), Szelke et al.
Bajusz, S., et al. (1978) Int. J. Peptide and Protein Res., 12:217-221. Inhibition of Thrombin and Trypsin by Tripeptide Aldehydes.
Chang, J.-Y, (1985) Eur. J. Biochem. 151:217-224. Thrombin specificity.

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