Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1994-08-18
1997-01-14
Conrad, Joseph
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
562 11, 562 15, 562443, 562444, 562445, 562448, 562449, 562493, 562561, 562622, 562623, 564305, 564440, 564453, 564457, 564500, A61K 3100
Patent
active
055941060
ABSTRACT:
Compounds and methods are disclosed that are useful in inhibiting the TNF-.alpha. converting enzyme (TACE) responsible for cleavage of TNF-.alpha. precursor to provide biologically active TNF-.alpha.. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.
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Black Roy A.
Fitzner Jeffrey N.
Sleath Paul R.
Conrad Joseph
Immunex Corporation
Malaska Stephen L.
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