Inhibitors of TNF-.alpha. secretion

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

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562 11, 562 15, 562443, 562444, 562445, 562448, 562449, 562493, 562561, 562622, 562623, 564305, 564440, 564453, 564457, 564500, A61K 3100

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active

055941060

ABSTRACT:
Compounds and methods are disclosed that are useful in inhibiting the TNF-.alpha. converting enzyme (TACE) responsible for cleavage of TNF-.alpha. precursor to provide biologically active TNF-.alpha.. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.

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