Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-07-06
1993-03-23
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 14, 530326, 530327, 530325, 530324, 623 11, A61K 3702, C07K 708, C07K 710
Patent
active
051964040
ABSTRACT:
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association moiety (ABEAM); a linker portion of at least 18 .ANG. in length; and a thrombin catalytic site-directed moiety (CSDM). This invention also relates to compositions, combinations and methods which employ these molecules for therapeutic, prophylactic and diagnostic purposes.
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Fenton, II John W.
Kline Toni
Maraganore John M.
Biogen Inc.
Haley, Jr. James F.
Health Research , Inc.
Lee Lester L.
Marks Andrew S.
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