Inhibitors of the S100-p53 protein-protein interaction and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S718000, C435S007100

Reexamination Certificate

active

08053477

ABSTRACT:
Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.

REFERENCES:
patent: 6693125 (2004-02-01), Borisy et al.
patent: 2002/0165261 (2002-11-01), Borisy et al.
patent: WO 92/08464 (1992-05-01), None
patent: WO 00/45165 (2000-08-01), None
patent: WO 01/35935 (2001-05-01), None
Cecil Textbook of Medicine, 21st Edition (2000), Goldman & Bennett (Editors), W.B. Saunders Company (Publisher), Chapter 198, pp. 1060-1074.
Stedman's Medical Dictionary, 2nd Edition (electronic version), 2000, Lippincott Williams & Wilkins, <<http://www.thomsonhc.com/pdrel/librarian>>; retrieved via the PTO NPL website on Aug. 24, 2005.
Jackel et al. “S-100-beta Protein im Serum als Tumormarker beim malignen Melanom”. Hautarzt. 50, 1999:250-256. [English Abstract at p. 251].
Nastruzzi et al. “Effects of Benzamidine Derivatives on Ha-ras-1 mRNA Accumulation in a Chinese Hamster Cell Line Transformed with the Activated Human T24 Ha-ras-1 Oncogene”. Anticancer Research. 8, 1988:269-273.
Bornstein et al. “An Evaluation of the Mechanism of Action of Pentamidine Isethionate”. Journal of Surgical Oncology. 2(4), 1970:393-398.
Bartolazzi et al. “Antitumor Activity of the Proteinase Inhibitor Tetra-p-amidinophenoxyneopentane in a Nude Mouse Model of Human Melanoma.” In Vivo. 3, 1989:383-387.
Nastruzzi et al. “Inhibition of ‘in vitro’ Tumor Cell Growth by Aromatic Polyamidines Exhibiting Antiproteinase Activity”. Clin. Expl. Metastasis. 7(1), 1989:25-39.
Lin et al. “Inhibition of p53 Transcriptional Activity by the S100B Calcium-Binding Protein”. Journal of Biological Chemistry, 276(37); 2001:35037-35041.
Pathak et al,Mol. Cancer Therapeutics, 1:1255-1264 (2002).
Jenkins et al,Eur. J. Biochem., 213:1175-1184 (1993).
Barrett et al,Parasitoloty, 16(1):7-9 (2000).
Kopac, “Section of Biology”,The New York Academy of Science, pp. 5-10 (Oct. 8, 1945).
Bailly et al,Biochem. J., 323:23-31 (1997).
Nandi et al,J. Indian. Chem. Sci., 70:527-531 (1993).
O'Conner et al,Cancer Res., 57:4285-4300 (1997).
Perez et al,Chem. Biol. Interactions, 77:341-355 (1991).
Perez et al,Chemio-Biol. Interactions, 89:61-72 (1993).
Donato, R. “Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type” Biochimica ET Biophysica Acta. Molecular Cell Research, Elsevier Science Publishers, Amsterdam, NL, vol. 1450, No. 3, Jul. 8, 1999, pp. 191-231.
Jing Lin et al. “Inhibition of p53 transcriptional activity by S100B calcium-binding protein” The Journal of Biological Chemistry, vol. 276, No. 37, Sep. 14, 2001, pp. 35037-35041.
Supplemental European Search Report for European Patent Application No. 03723795.5, Issue Date: Dec. 11, 2007.

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